Summary
Sylvaticin (I), a new tetrahydroxy annonaceous acetogenin with nonadjacent tetrahydrofuran rings, has been isolated from the dried fruits ofRollinia sylvatica St. Hil. (Annonaceae). This compound is extremely cytotoxic to human tumor cells and shows promising insect control properties.
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Jolad, S. D., Hoffmann, J. J., Schram, K. H., Cole, J. R., Tempesta, M. S., Kriek, G. R., and Bates, R. B., J. org. Chem.47 (1982) 151.
Jolad, S. D., Hoffmann, J. J., Cole, J. R., Barry III, C. E., Bates, R. B., Linz, G. S., and Konig, W. A., J. nat. Prod.48 (1985) 644.
Dabrah, T. T., and Sneden, A. T., Phytochemistry23 (1984) 2013.
Dabrah, T. T., and Sneden, A. T., J. nat. Prod.47 (1984) 652.
Etse, J. T., and Waterman, P. G., J. nat. Prod.49 (1986) 684.
Cortes, D., Rios, J. L., Villar, A., and Valverde, S., Tetrahedron Lett.25 (1984) 3199.
Rupprecht, J. K., Chang, C.-J., Cassady, J. M., McLaughlin, J. L., Mikolajczak, K. L., and Weisleder, D., Heterocycles24 (1986) 1197; Mikolajczak, K. L., McLaughlin, J. L., and Rupprecht, J. K., U.S. Patent No. 4, 721, 727 (issued Jan. 26, 1988).
McCloud, T. G., Smith, D. L., Chang, C.-J., and Cassady, J. M., Experientia43 (1987) 947.
Pettit, G. R., Cragg, G. M., Polonsky, J., Herald, D. L., Goswami, A., Smith, C. R., Moretti, C., Schmidt, J. M., and Weisleder, D., Can. J. Chem.65 (1987) 1433.
Alkofahi, A., Rupprecht, J. K., Smith, D. L., Chang, C.-J., and McLaughlin, J. L. Experientia44 (1988) 83.
Fujimoto, Y., Eguchi, T., Kakinuma, K., Ikekawa, N., Sahai, M., and Gupta, Y. K., Chem. pharm. Bull.36 (1988) 4802.
Pettit, G. R., Riesen, R., Leet, J. E., Polonsky, J., Smith, C. R., Schmidt, J. M., Dufresne, C., Schaufelberger, D., and Moretti, C., Heterocycles28 (1989) 213.
Born, L., Lieb, K., Lorentzen, J. P., Moeschler, H., Nonfon, M., Sollner, R., and Wendisch, D., Planta med. (1989) in press.
Abreo, M. L., and Sneden, A. T., J. nat. Prod. (1989) in press.
Hui, Y.-H., Rupprecht, J. K., Liu, Y.-M., Anderson, J. E., Smith, D. L., Chang, C.-J., and McLaughlin, J. L., J. nat. Prod.52 (1989) 463; McLaughlin, J. L., and Hui, Y.-H., Chemotherapeutically active acetogenins, U.S. Patent, applied for April 11, 1989.
Lieb, F., Nonfon, M., Wachendorff-Neumann, U., and Wendisch, D., Planta med. (1989) in press.
Alkofahi, A., Rupprecht, J. K., Liu, Y.-M., Chang, C.-J., Smith, D. L., and McLaughlin, J. L., Experientia46 (1990) in press.
Hui, H.-Y., Rupprecht, J. K., Anderson, J. E. Liu, Y.-M., Smith, D. L., Chang, C.-J., and McLaughlin, J. L., Tetrahedron, accepted for publication.
Meyer, B. N., Ferrigni, N. R., Putnam, J. E., Jacobsen, L. B., Nichols, D. E., and McLaughlin, J. L., Planta med.45 (1982) 31.
Reed, D. K., Warthen, J. D., Jr., Uebel, E. C., and Reed, G. L., J. econ. Ent.75 (1982) 1109.
Hoye, T. R., and Suhadolnik, J. C., J. Am. chem. Soc.109 (1987) 4402.
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Mikolajczak, K.J., Madrigal, R.V., Rupprecht, J.K. et al. Sylvaticin: A new cytotoxic and insecticidal acetogenin fromRollinia sylvatica (Annonaceae). Experientia 46, 324–327 (1990). https://doi.org/10.1007/BF01951779
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DOI: https://doi.org/10.1007/BF01951779