Summary
Platelet activating factor (PAF) induces a biphasic effect on guinea-pig papillary muscle: 1. a transient positive inotropic effect preceded by an increase in action potential duration (APD); 2. a marked negative effect on inotropism and on APD. Since Ca++ slow action potentials were initially enhanced by PAF and then markedly depressed, it is suggested that PAF specifically interferes with the Ca++ slow channel.
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Camussi, G., Alloatti, G., Montrucchio, G. et al. Effect of platelet activating factor on guinea-pig papillary muscle. Experientia 40, 697–699 (1984). https://doi.org/10.1007/BF01949729
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DOI: https://doi.org/10.1007/BF01949729