Summary
The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. Many important pharmaceutical properties have been ascribed to propolis, including anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Propolis extracts have provided an active component identified as caffeic acid phenethyl ester (CAPE), which was readily prepared in one step. Differential cytotoxicity has been observed in normal rat/human versus transformed rat/human melanoma and breast carcinoma cell lines in the presence of CAPE.
Article PDF
Avoid common mistakes on your manuscript.
References
Tóth, G., Am. Bee J.125 (1976) 337.
Cizmárik, J., and Matel, I., Experientia15 (1970) 713.
Bankova, V. S., Popov, S. S., and Marekov, N. L., J. nat. Prod.46 (1983) 474.
Hladon, B., et al., Arzneim.-Forsch./Drug Res.30 (1980) 1847.
Fisher, P. B., Babiss, L. E., Weinstein, I. B., and Ginsberg, H. S., Proc. natl Acad. Sci. USA79 (1982) 3527.
Eisinger, M., Marko, O., Ogata, S.-I., and Old, L. J., Science229 (1985) 984.
Herald, P. J., and Davidson, P. M., J. Food Sci.48 (1983) 1378.
Koshihara, Y., et al., Biochim. biophys. Acta792 (1984) 92.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Grunberger, D., Banerjee, R., Eisinger, K. et al. Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia 44, 230–232 (1988). https://doi.org/10.1007/BF01941717
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01941717