Summary
Epimastigotes ofTrypanosoma cruzi (Tulahuen strain Tul 0 stock) biotransform benznidazole (N-benzyl-2-nitro-1-imidazone acetamide) to reactive metabolites that bind covalently to DNA, proteins and lipids of the parasite. These effects might be related to the trypanocidal action of benznidazole, a chemotherapeutic agent against Chagas' disease.
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Díaz de Toranzo, E.G., Castro, J.A., Franke de Cazzulo, B.M. et al. Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids fromTrypanosoma cruzi. Experientia 44, 880–881 (1988). https://doi.org/10.1007/BF01941187
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DOI: https://doi.org/10.1007/BF01941187