Abstract
Exposure of voltage-clamped frog skeletal muscle fibres to silver caused a maintained inward current which could be carried by Ca2+, Mg2+ or Na+. Inorganic Ca2+ channel blockers and dithiothreitol (SH reducing agent) diminished this current, but a Na+ channel blocker did not. Thus, silver activates the Ca2+ channel by acting on SH groups in a Ca2+ channel protein.
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Aoki, T., Nihonyanagi, K. & Oba, T. Involvement of thiols in the induction of inward current induced by silver in frog skeletal muscle membrane. Experientia 49, 792–794 (1993). https://doi.org/10.1007/BF01923550
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DOI: https://doi.org/10.1007/BF01923550