Summary
Lead was given in the diet (1%) to rats from birth and at different times the animals were studied for delta amino levulinic acid dehydratase (ALAD) activity, spleen weight,59Fe incorporation in erythrocytes and51Cr-labeled erythrocytes survival. The increased ALAD and spleen weight found after lead treatment is explained as a consequence of a shortened survival, which results in a younger age of circulating erythrocytes with higher ALAD activity.
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Supported by Contract No. 140-76-12 ENV. B. of the E. C. Environmental Research Program.
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Maes, J., Gerber, G.B. Increased ALA dehydratase activity and spleen weight in lead-intoxicated rats. A consequence of increased blood cell destruction. Experientia 34, 381–382 (1978). https://doi.org/10.1007/BF01923048
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DOI: https://doi.org/10.1007/BF01923048