Summary
Different biological effects of Ag+ (10−4 M) were found depending on its presence in the outer or the inner solution bathing the frog skin. A marked increase in the electrical conductance and an interference with the action of oxytocin and amiloride were found only when Ag+ was added to the outer solution. Results suggest that Ag+ affects several transport processes, in particular the permeability of the Na entry pathways.
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References
P. F. Curran, Biochim. biophys. Acta288, 90 (1972).
K. T. G. Ferreira, Biochim. biophys. Acta203, 555 (1970).
L. N. Fleisher, T. Yorio and P. J. Bentley, Toxic. appl. Pharmac.33, 384 (1975).
R. C. De Sousa, J. Marguerat and A. Grosso, Experientia29, 748 (1973).
Y. Yorio and P. J. Bentley, Comp. gen. Pharmac.4, 167 (1973).
J. Marguerat, Thesis, University of Geneva, Geneva (1975).
J. Yonath and M. M. Civan, J. Memb. Biol.5, 366 (1971).
R. C. De Sousa, J. Physiol.71, 5A (1975).
J. Marguerat and R. C. De Sousa, Experientia31, 73 (1975).
J. H. Li, unpublished results.
A. W. Cuthbert, Molec. Pharmac.10, 892 (1974).
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This work was supported by the Swiss National Science Foundation, grant No. 1.300.73. We thank Mrs A. Cergneux for skilful secretarial assistance.
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Li, J.H., de Sousa, R.C. Effects of Ag+ on frog skin: Interactions with oxytocin, amiloride and ouabain. Experientia 33, 433–436 (1977). https://doi.org/10.1007/BF01922195
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DOI: https://doi.org/10.1007/BF01922195