Abstract
Study and characterization of molecular complexes between cholesterol and beta cyclodextrin has been done using X-ray diffraction, thermogravimetric analysis (TG), differential scanning calorimetry (DSC) and nuclear magnetic resonance spectroscopy (13C NMR). Whatever the value of the molar ratio cholesterol/βCD used during the preparation, the same compound is always obtained. Corresponding to a molar ratio 1/3 (cholesterol/βCD), this compound is a stable hydrate which, contrary toβCD, contains at room temperature a large amount of molecules of water. It can be dehydrated under low pressure but the thermal degradation occurs at 200°C (250°C forβCD). This implies that cholesterol is strongly bounded toβCD.
Zusammenfassung
Mittels Röntgendiffraktion, TG, DSC und13C-NMR-Spektroskopie wurden Molekülkomplexe zwischen Cholesterol und Betacyclodextrin untersucht und charakterisiert. Unabhängig von dem bei der Herstellung angewendeten Cholesterol/ßCD-Verhältnis wurde immer die gleiche Verbindung erhalten. Bei einem Molverhältnis 1/3 (Cholesterol/BCD) ist diese Verbindung ein stabiles Hydrat, das im Gegensatz zu ßCD bei Raumtemperatur eine große Anzahl von Wassermolekülen enthält. Es kann in Vakuum dehydratiert werden, die thermische Zersetzung erfolgt bei 200°C (250°C für ßCD). Dies setzt voraus, daß Cholesterol fest an ßCD gebunden ist.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
M. L. Bender and M. Komiyama, Cyclodextrin Chemistry, Springer-Verlag, Berlin 1978.
J. Szejtli, Cyclodextrins and their Inclusion Complexes, Akadémiai Kiadó, Budapest 1982.
J. Szejtli, Carbohydrate Polymers, 12 (1990) 375.
P. Claudy, P. Germain, J. M. Létoffé, A. Bayol and B. Gonzalez, Thermochim. Acta, 161 (1990) 75.
H. Schlenk, D. Sand and J. A. Tillotson, U.S. Patent n∘ 2827452, 1958.
P. Claudy, P. Germain, J. M. Létoffé, A. Bayol, P. Bosserdet and B. Gonzalez, Colloque Bilan Aliment 2000, Paris 29–30 Janvier 1990.
R. Fridrich, W. Mehnert and K. H. Frömming, 5th International Symposium on Cyclodextrins, Paris 28–30 Mars 1990.
P. Claudy, G. Chahine, B. Bonnetot and J. M. Létoffé, Thermochim. Acta, 38 (1980) 75.
K. Koizumi, Y. Kubota, T. Tanimoto and Y. Okada, J. of Chromatography, 454 (1988) 303.
Y. Nakai, K. Yamamoto, K. Terada and D. Watanabe, Chem. Pharm. Bull., 35 (1987) 4609.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cloudy, P., Létoffé, J.M., Germain, P. et al. Physicochemical characterization of cholesterol-beta cyclodextrin inclusion complexes. Journal of Thermal Analysis 37, 2497–2506 (1991). https://doi.org/10.1007/BF01912796
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01912796