Conclusions
In conclusion, there is a shift in the population of IgG glycoforms towards those with a higher content of agalactosyl biantennary N-linked oligosaccharides in active rheumatoid arthritis (both juvenile and adult), tuberculosis, and Crohn's disease, but not in a variety of other rheumatological, inflammatory, or infectious conditions. This shift may contribute to disease pathogenesis both through immune-complex formation and through disturbance of a cellular network directed against the non-reducing terminal G1cNAc epitope. The precise pathology would in each case be modulated by the anatomical site(s) of production of such IgG, and also by the precise mechanism inducing this change in IgG glycosylation. Important amongst such mechanisms may be cross-reactivity between environmental and endogenous carbohydrate epitopes. It will be interesting to see if future research supports the idea that groups of diseases (e. g., rheumatoid arthritis, tuberculosis, Crohn's) are indeed related by a common aetiopathogenesis [i. e., G(0)].
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Rademacher, T.W., Parekh, R.B., Dwek, R.A. et al. The role of IgG glycoforms in the pathogenesis of rheumatoid arthritis. Springer Semin Immunopathol 10, 231–249 (1988). https://doi.org/10.1007/BF01857227
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DOI: https://doi.org/10.1007/BF01857227