Summary
The effects of i.v. injected 4-dimethylaminophenol·HCl, a ferrihemoglobin-forming substance, on cerebral blood flow, brain temperature, blood gases, and lactate concentration in the sinus sagittalis blood were measured on male beagle dogs anesthetized with chloralose.
An increase in cerebral blood flow became measurable when 5% or more of the hemoglobin was oxidized to ferrihemoglobin. The local cerebral blood flow of the cingulum region and the flow in the sinus sagittalis increased, while the sinus pO2 decreased. An increase in the ferrihemoglobin content of some 20% of the total hemoglobin at a constant arterial pO2 and pCO2 was attended with a decrease in the sinus pO2 of about 10 mm Hg when less than 40% of the heme iron was oxidized. The sinus pO2 approached a threshold value of some 8 mm Hg when the ferrihemoglobin content was increased above 40%. The lactate concentration began to rise very rapidly when 40–50% of the hemoglobin was oxidized. At the same time pCO2 increased and pH decreased in the sinus blood. The brain temperature remained unchanged. The behavior of conscious dogs with a ferrihemoglobin content of 40% of the total hemoglobin showed no abnormalities.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Betz E, Hensel H (1962) Fortlaufende Registrierung der lokalen Durchblutung im Inneren des Gehirns bei wachen, frei beweglichen Tieren. Pflügers Arch Ges Physiol 274:608–614
Betz E, Kozak R (1967) Der Einfluß der Wasserstoffionenkonzentration der Gehirnrinde auf die Regulation der corticalen Durchblutung. Pflügers Arch 293:56–67
Darling RC, Roughton FJW (1942) The effect of methemoglobin on the equilibrium between oxygen and hemoglobin. Am J Physiol 137:56–68
Gibbs FA (1933/1934) A thermoelectric blood flow recorder in the form of a needle. Proc Soc Exp Biol 31:141–146
Gibbs EL, Lennox WG, Nims LF, Gibbs FA (1942) Arterial and cerebral venous blood. Arterial venous differences in man. J Biol Chem 144:325–332
Golenhofen K, Hensel H, Hildebrandt G (1963) Durchblutungsmessung mit Wärmeleitelementen. Thieme, Stuttgart
Hensel H (1961) Durchblutungsmessung nach dem Prinzip der geheizten Thermoelemente: Kreislaufmessungen. Werk-Verlag Dr. Edmund Banaschewski, München-Gräfelfing
Ingvar DH (1958) Cortical state of excitability and cortical circulation, reticular formation of the brain stem. Little Brown, Ford Symposium Boston, p 387
Kiese M, Weger N (1969) Formation of ferrihemoglobin with aminophenols in the human for the treatment of cyanide poisoning. Eur J Pharmacol 7:97–105
Klimmek R, Fladerer H, Szinicz L, Weger N, Kiese M (1979a) Effects of 4-dimethylaminophenol and Co2EDTA on circulation, respiration, and blood homeostasis in dogs. Arch Toxicol 42:75–84
Klimmek R, Fladerer H, Weger N (1979b) Circulation, respiration, and blood homeostasis in cyanide-poisoned dogs after treatment with 4-dimethylaminophenol or cobalt compounds. Arch Toxicol 43, 121–133
MacMillan V, Siesjö Bo K (1971) Critical oxygen tensions in the brain. Acta Physiol Scand 82:412–414
Noell W, Schneider M (1943) Über die Durchblutung und die Sauerstoffversorgung des Gehirns im akuten Sauerstoffmangel. III. Mitteilung: Die arterio-venöse Sauerstoff- und Kohlensäuredifferenz. Pflügers Arch 246, 207–249
Noell W, Schneider M (1948) Quantitative Angaben über Durchblutung und Sauerstoffversorgung des Gehirns. Pflügers Arch 250:35–41
Noell W (1944) Über die Durchblutung und die Sauerstoffversorgung des Gehirns. VI. Mitteilung: Einfluß der Hypoxämie und Anämie. Pflügers Arch 247:553–575
Opitz E, Schneider M (1950) Über die Sauerstoffversorgung des Gehirns und den Mechanismus von Mangelwirkungen. Erg Physiol 46:126–260
Schmahl FW, Betz E, Dettinger E, Hohorst HJ (1966) Energiestoffwechsel der Großhirnrinde und Elektroencephalogramm bei Sauerstoffmangel. Pflügers Arch 292:46–59
Thews G (1960) Die Sauerstoffdiffusion im Gehirn. Ein Beitrag zur Frage der Sauerstoffversorgung der Organe. Pflügers Arch 271:197–226
Weger N (1969) Therapie der Blausäurevergiftung. Med Monatsschr 23:436–440
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Klimmek, R., Roddewig, C. & Weger, N. Effects of 4-dimethylaminophenol on blood flow and blood gases in the brain. Res. Exp. Med. 179, 141–151 (1981). https://doi.org/10.1007/BF01851982
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01851982