Abstract
The bioavailability of three formulations of ivermectin was determined following oral administration to dogs. The average peak plasma level (C max) of ivermectin administered in the standard tablet formulation at 6 and 100 µg/kg of body weight was 2.97 and 44.31 ng/g, respectively. This suggest dose-dependent pharmacokinetics.C max and total ivermectin bioavailability, as assessed from the area under the plasma curve (AUC), were similar between two tablet formulations of ivermectin administered at 100 µg/kg. Furthermore,C max was similar following administration of radiolabelled ivermectin at 6 µg/kg in either a beef-based chewable formulation or in the standard tablet formulation.
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Fink, D.W. and Porras, A.G., 1989. Pharmacokinetics of ivermectin in animals and humans. In: W.C. Campbell (ed),Ivermectin and Abamectin, (Springer-Verlag, New York), 113–130
Fisher, M.H. and Mrozik, H., 1989. Chemistry. I. Structures of the naturally occurring avermectins. In: W.C. Campbell (ed),Ivermectin and Abamectin, (Springer-Verlag, New York), 1–23
Kojima, K., Yamamoto, K., Nakanishi, Y. and Katae, H., 1987. Determination of 22,23-dihydroavermectin B1a in dog plasma using solid-phase extraction and high-performance liquid chromatography.Journal of Chromatography,413, 326–331
Paul, A.J., Todd, K.S., Acre, K.E., Plue, R.E., Wallace, D.H., French, R.A. and Wallig, M.A., 1991. Efficacy of ivermectin chewables and two new ivermectin tablet formulations againstDirofilaria immitis larvae in dogs.American Journal of Veterinary Research,52, 1922–1923
Plue, R.E., Acre, K.E., Coleman, M.W., Currin, S.T., Ellis, A.J. and George, L.W., 1989. Efficacy and field safety of two new ivermectin formulations for the prevention of canine heartworm disease. In: G.F. Otto (ed),Proceedings of the Heartworm Symposium '89, (American Heartworm Society, Washington, DC), 103–106
Schuirmann, D.J., 1987. A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability.Journal of Pharmacokinetics and Biopharmaceutics,15, 657–680
Stong, J.D., 1987. Determination of ivermectin by fluorescence derivatization.Analytical Chemistry,59, 266–270
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Daurio, C.P., Cheung, E.N., Jeffcoat, A.R. et al. Biovailability of ivermectin administered orally to dogs. Vet Res Commun 16, 125–130 (1992). https://doi.org/10.1007/BF01839009
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DOI: https://doi.org/10.1007/BF01839009