Summary
Takayasu arteritis is the commonest cause of renovascular hypertension in India. The clinical and radiological features, complications and course of 83 patients (51 females, 32 males) seen during the period from 1972–1990 are described in this study. The age of the patients ranged from 5 to 53 years with the mean ±SD of 26.9 ± 9.7. Hypertension (n = 50) and the related symptom of headache (n = 40), dyspnea (n = 24), and giddiness (n = 20) were common at presentation. Twelve patients were in congestive cardiac failure. The symptoms of activitly with fever and arthralgia were present in only 16% contrary to reports from Japan and Mexico. Abnormal arterial pulses and bruit over abdominal (37%) or extra abdominal great arteries (25%) were useful clinical clues to suspect Takayasu arteritis. Rapid sequence intravenous urography was a sensitive screening procedure and predicted correctly the presence of renovascular disease in 80% of the patients. The diagnosis was confirmed on aortography in 72. In the rest, the clinical features and autopsy findings confirmed the same. The four patterns of the disease based on the anatomical extent of involvement were recognised. These were: type I (n = 8) with involvement of aortic arch and its branches, type II (n = 25) descending thoracic and abdominal aorta type III (n = 46) combination of I and II and type IV (n = 4) pulmonary artery in addition to any of the above.
Antihypertensive drug therapy was the mainstay of treatment, but surgery in carefully selected patients was rewarding. Eleven patients died during 6 years after the initial diagnosis mainly due to cardiac, renal and cerebro-vascular complications. The course of the disease seems to be slowly progressive and in many patients becomes static for long periods.
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Sharma, B.K., Sagar, S., Singh, A.P. et al. Takayasu arteritis in India. Heart Vessels 7 (Suppl 1), 37–43 (1992). https://doi.org/10.1007/BF01744542
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DOI: https://doi.org/10.1007/BF01744542