Summary
In an attempt to elucidate the significance of ACTH independent mechanisms in the regulation of cortisol secretion in man, the dynamics of plasma ACTH and cortisol levels were studied in response to different stimuli. The cortisol response to small amounts of exogenous ACTH and to insulin induced hypoglycemia was preceded by an increase in ACTH levels appropriate to explain the increase in cortisol. In contrast, after administration of methamphetamine, there was an increase in cortisol levels in the absence of any changes in ACTH concentrations. Apparently, the methamphetamine induced cortisol secretion was not mediated by radioimmunoassayable ACTH. A diurnal rhythm was observed for the responses to hypoglycemia and to methamphetamine with larger cortisol responses in the evening as compared to the forenoon. These changes were not accompanied by parallel changes in the ACTH responses. From these differences, additional evidence is provided for the importance of ACTH independent mechanisms in the regulation of cortisol secretion.
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Allen-Rowland CF, Allen JP, Greer MA, Wilson M (1980) Circadian rhythmicity of ACTH and corticosterone in the rat. J Endocrinol Invest 4:371–377
Besser GM, Butler PWP, Landon J, Rees L (1969) Influence of amphetamines on plasma corticosteroid and growth hormone levels in man. Br Med J 4:528–530
Besser GM, Butler PWP, Ratcliffe JG, Rees L, Young P (1970) Release by amphetamine in man of growth hormone and corticosteroids: the effects of thymoxamine and propranolol. Br J Pharmacol 39:166P-170P
Brandenberger G, Follenius M (1973) Variations diurnes de la cortisolémie, de la glycémie et du cortisol libre urinaire chez l'homme au repos. J Physiol Paris 66:271–282
Brown WA, Corriveau DP, Ebert MH (1978) Acute psychologic and neuroendocrine effects of dextroamphetamine and methylphenidate. Psychopharm 58:189–195
Checkley SA (1979) Corticosteroid and growth hormone responses to methylamphetamine in depressive illness. Psychol Med 9:107–115
Cohen Mr, Nurnberger JI, Pichar D, Gershon E, Bunney WE jr (1981) Dextroamphetamine infusion in normals result in correlated increases of plasma β-endorphin and cortisol immunoreactivity. Life Sci 29:1243–1247
Dallman MF, Engeland WC, Rose JC, Wilkinson CW, Shinsako J, Siedenburg F (1978) Nycthemeral rhythm in adrenal responsiveness to ACTH. Am J Physiol 235:210–218
De Souza EB, van Loon GR (1982) Stress-induced inhibition of the plasma corticosterone response to a subsequent stress in rats. A nonadrenocorticotropin-mediated mechanism. Endocrinology 110:23–33
Donald RA (1971) Plasma immunoreactive corticotrophin and cortisol response to insulin hypoglycemia in normal subjects and patients with pituitary disease. J Clin Endocrinol 32:225–231
Engeland WC, Dallman MF (1976) Neural mediation of compensatory adrenal growth. Endocrinology 99:1659–1662
Estler CJ (1978) Effect of amphetamine-type psychostimulants on brain metabolism. Adv Pharmacol Chemother 13:305–357
Fehm HL, Voigt KH, Pfeiffer EF (1972) Problems and artefacts in ACTH assay. Horm Metab Res 4:477–481
Follenius M, Brandenberger G, Hietter B (1982) Diurnal cortisol peaks and their relationship to meals. J Clin Endocrinol Metab 55:757–761
Gerendai J, Kiss J, Molnár J, Halász B (1974) Further data on the existence of a neural pathway from the adrenal gland to the hypothalamus. Cell Tiss Res 152:559–564
Gibson MJ, Krieger DT (1981) Circadian corticosterone rhythms and stress response in rats with adrenal autotransplants. Am J Physiol 240:E363-E366
Halász B, Szentágothai J (1959) Histologischer Beweis einer nervösen Signalübermittlung von der Nebennierenrinde zum Hypothalamus. Zeitschr Zellforsch 50:297–306
Halbreich U, Sachar EJ, Asnis GM, Nathan RS, Halpern FS (1981) Diurnal cortisol responses to dextroamphetamine in normal subjects. Psychoneuroendocrinology 6:223–229
Ichikawa Y, Nishikai M, Kawagoe M, Yoshida K, Homma M (1972) Plasma corticotropin, cortisol and growth hormone responses to hypoglycemia in the morning and evening. J Clin Endocrinol 34:895–898
Kaneko M, Hiroshige T, Shinsako J, Dallman MF (1980) Diurnal changes in amplification of hormone rhythms in the adrenocortical system. Am J Physiol 239:309–316
Kaneko M, Kaneko K, Shinsako J, Dallman MF (1981) Adrenal sensitivity to adrenocorticotropin varies diurnally. Endocrinology 109:70–75
Kiss T (1951) Experimentell-morphologische Analyse der Nebenniereninnervation. Acta Anat (Basel) 13:81–89
Kovách AGB, Monos E, Koltay E, Desrius A (1970) Effect of hypothalamic stimulation on adrenal blood flow and glucocorticoid release prior to and after acute hypophysectomy. Acta Physiol (Hung) 38:205–216
Krieger DT, Liotta AS, Suda T, Goodgold A, London E (1979) Human plasma immunoreactive lipotropin and adrenocorticotropin in normal subjects and in patients with pituitary-adrenal disease. J Clin Endocrinol Metab 48:566–571
Meier AH (1976) Daily variation in concentration of plasma corticosteroid in hypophysectomized rats. Endocrinology 98:1475–1479
Moore KE (1978) Amphetamines: biochemical and behavioral actions in animals. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of Psychopharmacology, vol 11. Plenum Press, New York, pp 47–98
Murakami N, Takahashi K (1982) Circadian adrenocortical rhythm in the adrenalectomized rat with or without autotransplanted adrenal gland. Neuroendocrinology 34:157–162
Murphy BEP (1967) Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J Clin Endocrinol Metab 27:973–990
Ottenweller JE, Meier AH, Ferrell BR, Horseman ND, Proctor A (1978) Extrapituitary regulation of the circadian rhythm of plasma corticosteroid concentration in rats. Endocrinology 103:1875–1879
Ottenweller JE, Meier AH (1982) Adrenal innervation may be an extrapituitary mechanism able to regulate adrenocortical rhythmicity in rats. Endocrinology 111:1334–1338
Quigley ME, Yen SSC (1979) A mid-day surge in cortisol levels. J Clin Endocrinol Metab 49:945–947
Rees L, Butler PWP, Gosling C, Besser GM (1970) Adrenergic blockade and the corticosteroid and growth hormone responses to methylamphetamine. Nature 228:565–566
Sachar EJ, Asnis G, Nathan RS, Halbreich U, Tabrizi MA, Halpern FS (1980) Dextroamphetamine and cortisol in depression. Arch Gen Psychiat 37:755–757
Staub JJ, Jenkins JS, Ratcliffe JG, Landon J (1973) Comparison of corticotrophin and corticosteroid response to lysine vasopressin, insulin and pyrogen in man. Br Med J 1:267–269
Unsicker K (1971) On the innervation of the rat and pig adrenal cortex. Z Zellforsch 116:151–156
Ventura MA, Gonzalo LM, Goñi FM (1976) Corticosterone secretion after neurogenic stress in intact and hypophysectomized rats. Experientia 33:686–687
Voigt KH, Fehm HL, Reck R, Pfeiffer EF (1974) Spontaneous and stimulated secretion of QUSO-extractable immunoassayable ACTH in man. Klin Wochenschr 52:516–621
Wilkinson CW, Shinsako J, Dallman MF (1981) Return of pituitary-adrenal function after adrenal enucleation or transplantation: diurnal rhythms and responses to ether. Endocrinology 109:162–169
Wilkinson CW, Shinsako J, Dallman MF (1982) Rapid decreases in adrenal and plasma corticosterone concentrations after drinking are not mediated by changes in plasma adrenocorticotropin concentrations. Endocrinology 110:1599–1606
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Supported by Deutsche Forschungsgemeinschaft (SFB 87, Projekt B2, B13. Heisenberg-Stipendium for K.H.V.)
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Fehm, H.L., Holl, R., Steiner, K. et al. Evidence for ACTH-unrelated mechanisms in the regulation of cortisol secretion in man. Klin Wochenschr 62, 19–24 (1984). https://doi.org/10.1007/BF01725188
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DOI: https://doi.org/10.1007/BF01725188