Abstract
A prospective study was undertaken to assess the relationship between recrudescent herpes labialis and host iron status. Forty-one patients with recrudescent herpes labialis, proven by herpes simplex virus isolation, were studied along with an equal number of age-and-sex matched control subjects. The iron status of patients and controls were assessed by haematine assay of ferritin. The iron (ferritin) level in patients with recrudescent herpes labialis was significantly (p<0.01) lower than in the control group. Only one patient was anaemic. Sideropenia appears to be a common finding in patients with recrudescent herpes labialis. The relationship between sideropenia and recrudescent herpes labialis requires further study as it may have implications for the management of the disease.
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References
Hall R, Malia RG: Medical laboratory haematology. Butterworth-Heinmann, Oxford, 1991, p. 226.
Sherman AR: Zinc, copper and iron nutriture and immunity. Journal of Nutrition 1992, 122, Supplement 3: 604–609.
Chandra RK: Nutrition and immune responses. Canadian Journal of Physiology and Pharmacology 1983, 61: 290–294.
Ward CG: Iron and immunologic function. Journal of Burn Care and Rehabilitation 1987, 8: 487–491.
Brubaker RR: Mechanisms of bacterial virulence. Annual Review of Microbiology 1985, 39: 21–50.
Weinberg ED: Nutritional immunity. Host's attempt to withhold iron from microbial invaders. Journal of the American Medical Association 1975, 231: 39–41.
Bullen JJ, Rogers HJ: Bacterial iron metabolism and resistance to infection. Journal of Medical Microbiology 1970, 3: 8–9.
Fuchs D, Zangerle R, Artner-Dworzak E, Wiss G, Fritsch P, Tilz GP, Dierich MP, Wachter H: Association between immune activation, changes in iron metabolism and anaemia in patients with HIV infection. European Journal of Haematology 1993, 50: 90–94.
Oppenheimer S, Hendrickse R: The clinical effects of iron deficiency and iron supplementation. Nutrition Abstracts and Reviews 1983, 53: 585–598.
Nahmias AJ, Keyserling H, Francis KL: Herpes simplex viruses 1 and 2. In: Evans AS (ed): viral infection of humans epidemiology and control. Plenum, New York, 1989, p. 393–417.
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Lamey, P.J., Biagioni, P.A. Relationship between iron status and recrudescent herpes labialis. Eur. J. Clin. Microbiol. Infect. Dis. 14, 604–605 (1995). https://doi.org/10.1007/BF01690734
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DOI: https://doi.org/10.1007/BF01690734