Summary
Activated charcoal and phenobarbital have both been proposed as agents for reducing accumulations of dieldrin in the body. Rats maintained on diets containing 2 ppm dieldrin spiked with dieldrin-14c were fed 0 and 1 g charcoal and 0, 40, and 80 mg phenobarbital per kg body weight in 2×3 factorial experiments. Measurements were made of the carbon-14 accumulated in the carcasses and excreted in the feces and urine. In one experiment, charcoal effectively reduced dieldrin storage in tissues when fed simultaneously with the pesticide; but, in another experiment, it was ineffective in reducing dieldrin residues when fed after storage of the pesticide had occurred and dieldrin feeding was stopped. Phenobarbital, a potent inducer of drugmetabolizing enzymes in the liver, dramatically reduced dieldrin storage whether fed simultaneously with dieldrin or following dieldrin accumulation.
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Engebretson, K.A., Davison, K.L. Dieldrin accumulation and excretion by rats fed phenobarbital and carbon. Bull. Environ. Contam. Toxicol. 6, 391–400 (1971). https://doi.org/10.1007/BF01684358
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DOI: https://doi.org/10.1007/BF01684358