Abstract
Ovarian cancer is the most malignant cancer in women, where it is the fifth leading cause of cancer-related death. The disease and its treatment have considerable effects on the quality of life of patients with this cancer. This study reviews existing literature on quality of life in patients with ovarian cancer to demonstrate the importance of the topic, to comment on improvements achieved and to consider their implications for the implementation of optimal treatment. A literature search was carried out through MEDLINE and of published papers on quality of life in patients with ovarian cancer from 1976 to 1994. Twenty papers have been reviewed, of which, 10 were treatment-related assessments of quality of life and the remaining 10 dealt with different topics including psychometric issues in measuring health-related quality of life. Twenty-four instruments were employed to measure quality of life. Of these, the Rotterdam Symptom Checklist (RSCL) and The European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) were found to be the most appropriate. Although meta-analysis of results is impossible, it appears that debulking surgery followed by platinum-based chemotherapy could improve both quality of life and survival. In addition to effective and efficient treatment, psychological counselling, palliative and home care, nutritional support and pain relief are the most important areas for improving quality of life of patients with ovarian cancer. Knowledge and insight into the quality of life of patients with ovarian cancer are still limited, and a large carefully planned international study is required. Use of existing standard measures is preferable and agreement should be reached on a selected single instrument.
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Aaronson NK, Beckmann JH (eds) (1987) The quality of life of cancer patients. Raven Press, New York
Aaronson NK, Ahmedzai S, Bergman B, et al (1993) The European Organisation for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376
Anderson B (1994) Quality of life in progressive ovarian cancer. Gynaecol Oncol 55: S151-S155
Austoker J (1994) Screening for ovarian, prostatic, and testicular cancers. Br Med J 309:315–320
Black RJ, Sharp L, Kendrick SW (1993) Trends in cancer survival in Scotland: 1968–1990. Information and Statistics Division—NHS in Scotland, Edinburgh, p 44
Bliss JM, Selby PJ, Robertson B, Powles TJ (1992) A method for assessing the quality of life of cancer patients: replication of the factor structure. Br J Cancer 65:961–966
Blythe JG, Wahl TP (1982) Debulking surgery: does it increase the quality of survival? Gynaecol Oncol 14:396–408
Bos-Branolte G, Zielstra EM, Rijshouwer YM, Duivenvoorden HJ (1988) Psychotherapy in patients cured of gynaecologic cancers. Recent Results Cancer Res 108:277–288
Boyd NF, Selby PJ, Sutherland HJ, Hogg S (1988) Measurement of the clinical status of patients with breast cancer: evidence for the validity of self assessment with linear analogue scales. J Clin Epidemiol 41:243–250
Coates A, Dillenbeck CF, McNeil DR, et al (1983) On the receiving end. II. Linear analogue self-assessment (LASA) in evaluation of aspect of the quality of life of cancer patients receiving therapy. Eur J Cancer Clin Oncol 19:1633–1637
Coates A, Abraham S, Kaye SB, et al (1983) On the receiving end-patient perception of the side-effects of cancer chemotherapy. Eur J Cancer Clin Oncol 19:203–208
Crowther ME, Corney RH, Shepherd JH (1994) Psychosexual implications of gynaecological cancer. Talk about it. Br Med J 308:869–870
Fallowfield LJ (1993) Quality of life measurement in breast cancer. J R Soc Med 86:10–12
Fayers PM, Jones DR (1983) Measuring and analysing quality of life in cancer clinical trials: a review. Statist Med 2:429–446
Furst CJ, Johansson S, Fredikson M, Hursti T, Steineck G, Peterson C (1992) Control of cisplatin induced emesis — a multidisplinary intervention strategy. Med Oncol Tumour Pharmacother 9:81–86
Ganz PA (1994) Quality of life and the patient with cancer: individual and policy implications. Cancer 74:1445–1452
Ganz PA, Haskell CM, Figlin RA, La Soto N, Siau J (1988) Estimating the quality of life in clinical trial of patients with metastatic lung cancer using the Karnofsky Performance Status and the Functional Living Index-Cancer. Cancer 61:849–856
Gillis CR, Hole DJ, Still RM, Davis J, Kaye SB (1991) Medical audit, cancer registration, and survival in ovarian cancer. Lancet 337:611–612
Gotay CC, Moore TD (1992) Assessing quality of life in head and neck cancer. Qual Life Res 1:5–17
Granai CO (1992) Ovarian cancer — unrealistic expectations. N Engl J Med 373:194–200
Guidozzi F (1993) Living with ovarian cancer. Gynaecol Oncol 50:202–207
Haes JCJM de, Knippenberg FCE van (1985) The quality of life of cancer patients: a review of the literature. Soc Sci Med 20:809–817
Haes JCJM de, Raatgever JW, Burg MEL ven der, Hamersma E, Neijt JP (1987) Evaluation of the quality of life of patients with advanced ovarian cancer treated with combination chemotherapy. In: Aaronson NK, Beckman J (eds) The quality of life of cancer patients. Raven Press, New York, pp 215–226
Haes JCJM de, Knippenberg FCE van, Nejit JP (1990) Measuring psychological and physical distress in cancer patients: structure and application of Rotterdam Symptom Checklist. Br J Cancer 62:1034–1038
Hays RD, Anderson R, Revicki D (1993) Psychometric consideration in evaluating health-related quality of life. Qual Life Res 2:441–449
Hole D, Gillis CR (1993) Use of cancer registry data to evaluate the treatment of ovarian cancer on hospital basis. Health Rep 5:117–119
Hopwood P, Stephens RJ, Machin D (1994) Approaches to the analysis of quality of life data: experiences gained from a Medical Research Council Lung Cancer Working Party palliative chemotherapy trial. Qual Life Res 3:339–352
Janicke F, Holscher M, Kuhn W, et al (1992) Radical surgical procedure improves survival time in patients with recurrence ovarian cancer. Cancer 70:2129–2136
Jenkinson C (1994) Quality of life measurement: does it have a place in routine clinical assessment? J Psychsom Res 38:377–381
Junor EJ, Hole DJ, Gillis CR (1994) Management of ovarian cancer: referral to a multidisciplinary team matters. Br J Cancer 70:363–370
King LA, Carson LF, Konstantinides N, et al (1993) Outcome assessment of home parenteral nutrition in patients with gynecologic malignancies: what have we learned in a decade of experience? Gynaecol Oncol 51:377–382
Levi F, Franceschi S, La Vecchia C, Ruzicka J, Gloor E, Randimbison L (1993) Epidemiologic pathology of ovarian cancer from the Vaud Cancer Registry, Switzerland. Ann Oncol 4:289–294
Maguire P, Selby P (1989) Assessing quality of life in cancer patients. Br J Cancer 60:437–440
Malone M, Harris AL, Luscombe DK (1994) Assessment of the impact of cancer on work, recreation, home management and sleep using a general health status measure. J R Soc Med 87:386–389
Markman M (1994) Follow-up of the asymptomatic patient with ovarian cancer. Gynaecol Oncol 55: S134-S137
McDowell I, Newell C (1987) Measuring health: a guide to rating scales and questionnaires. Oxford University Press, New York, p 213
Mermelstein HT, Lesko L (1992) Depression in patients with cancer. Psycho-Oncology 1:199–215
Montazeri A (1994) A study on quality of life in patients with ovarian cancer (research proposal). West of Scotland Health Services Research News 12:6
Olschewski M, Schulgen G, Schumacher M, Altman DG (1994) Quality of life assessment in clinical cancer research. Br J Cancer 70:1–5
Osoba D (ed) (1991) Effect of cancer on quality of life. CRC Press, Boca Raton, Fla
Osoba D, Zee B, Pater J, Warr D, Kaizer L, Latreille J (1994) Psychometric properties and responsiveness of the EORTC Quality of Life Questionnaire (QLQ-C30) in patients with breast, ovarian and lung cancer. Qual Life Res 3:353–364
Ovesen BL, Allingstrup L, Hannibal J, Mortensen EL, Hansen OP (1993) Effect of dietary counselling on food intake, body weight, response rate, survival, and quality of life in cancer patients undergoing chemotherapy: a prospective randomised study. J Clin Oncol 11:2043–2049
Ovesen L, Hannibal J, Mortensen EL (1993) The interrelationship of weight loss, dietary intake, and quality of life in ambulatory patients with cancer of the lung, breast, and ovary. Nutr Cancer 19:159–167
Ozols RF, Young RC (1991) Ovarian cancer: where to next? Semin Oncol 18:307–310
Ozols RF, Young RC (1991) Chemotherapy of ovarian cancer. Semin Oncol 18:222–232
Payne SA (1992) A study of quality of life in cancer patients receiving palliative chemotherapy. Soc Sci Med 35:1505–1509
Petru E, Sevin BU, Averette HE, Koechli OR, Hilsenbeck S (1991) Long-term survival in stage II and IV ovarian cancer. Arch Gynaecol Obstet 249:87–93
Portenoy RK, Thaler HT, Kornblith AB, et al (1994) The Memorial Symptom Assessment Scale: an instrument for the evaluation of symptom prevalence, characteristics and distress. Eur J Cancer 30:1326–1336
Portenoy RK, Thaler HT, Kornblith AB, et al (1994) Symptom prevalence, characteristics and distress in a cancer population. Qual Life Res 3:183–189
Portenoy RK, Kornblith AB, Wong G, Vlamis V, Lepore JM, Loseth DB (1994) Pain in ovarian cancer patients: prevalence, characteristics, and associated symptoms. Cancer 74:907–915
Roberts CS, Rossetti K, Cone D, Cavanagh D (1992) Psychosocial impact of gynecologic cancer: a descriptive study. J Psychosoc Oncol 10(1):99–109
Schipper H, Clinch J, McMurray A, Levitt M (1984) Measuring the quality of life of cancer patients-the Functional Living Index-Cancer: development and validation. J Clin Oncol 2:472–483
Spitzer WO, Dobson AJ, Hall J, et al (1981) Measuring the quality of life of cancer patients: a concise QL-Index for use by physicians. J Chronic Dis 34:585–597
Tchekmedyian NS, Call DF (eds) (1990) Quality of life in current oncology practice and research. Oncology 4 (special issue)
Walczak JR, Brady M (1991) Comparison of quality of life (QOL) in ovarian cancer patients participating in a national cooperative group phase III randomised trial (abstract). Proc ASCO 10: A1185
Warde P, Strugeon JF, Fine S, Hogg SA, Boyd NF (1984) Quality of life assessment in patients with carcinoma of the ovary (abstract). Proc ASCO 3: C-266
Watson M, Law M, Maguire GP, et al (1992) Further development of a quality of life measure for cancer patients: the Rotterdam Symptom Checklist (revised). Psycho-Oncology 1:35–44
Willemse PB, Lith J van, Mulder NH, et al (1990) Risk and benefits of cisplatin in ovarian cancer. A quality-adjusted survival analysis. Eur J Cancer 26:345–352
Willemse PB, Assendelft PH van, Fontein DL, Kloppenburg M, Boonstra H, Vries EG de (1991) Carboplatin in the treatment of ovarian carcinom; as effective and less toxic in comparison with cisplatin (in Dutch). Ned Tijdschr Geneeskd 135:1588–1592
Williams C (1992) Ovarian and cervical cancer. Br Med J 304:1501–1504
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Montazeri, A., McEwen, J. & Gillis, C.R. Quality of life in patients with ovarian cancer: Current state of research. Support Care Cancer 4, 169–179 (1996). https://doi.org/10.1007/BF01682336
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DOI: https://doi.org/10.1007/BF01682336