Abstract
The effects of infusion of a 10% lipid emulsion containing equal proportions of long-chain and medium-chain triglyceride were studied in elective surgical patients and others receiving total parenteral nutrition (TPN). Nitrogen balance was better when the TPN patients received lipid containing medium-chain triglyceride than during a similar period when long-chain triglyceride alone was given. Only in the malnourished patients did the medium-chain triglyceride lipid emulsion produce a significant ketonemia. This emulsion was administered without side effects.
Résumé
Les effets produits par une perfusion d'une émulsion lipidique à 10% contenant des proportions égales de triglycérides à longue chaîne et de triglycérides à chaîne moyenne ont été étudiés chez des opérés soumis à une chirurgie élective et chez d'autres placés sous alimentation parentérale exclusive. L'équilibre azoté fut meilleur quand ces derniers reçurent des triglycérides à chaîne moyenne plutôt que des triglycérides à longue chaîne. C'est seulement chez les sujets dénutris que l'émulsion lipidique contenant des triglycérides à chaîne moyenne produisit une cétonémie significative. Elle ne provoqua pas d'effets secondaires.
Resumen
Los efectos de ahorro proteico de las emulsiones de lípidos que contienen triglicéridos de cadena larga (TCL) han sido bien documentados, pero los efectos de los triglicéridos de cadena media (TCM) sobre el metabolismo proteico en el nombre no han sido investigados en detalle. Realizamos dos estudios separados en humanos para comparar una emulsión de TCL con un lípido que contiene TCM, una solución al 10% que está constituída por iguales proporciones de TCL y TCM. Los efectos de la emulsión de lípido al 10% con iguales proporciones de TCL y TCM fueron estudiados en pacientes sometidos a cirugía electiva y en pacientes malnutridos en regímenes de nutrición parenteral total (NPT). El balance de nitrógeno fue mejor cuando el regimen de NPT administrado contenía lípidos con TCM, al compararlo con regímenes que sólo contenían lípidos con TCL. Unicamente en los pacientes malnutridos se observó cetonemia de significación producida por la emulsión lípida de TCM. Las emulsiones lípidas con TCM fueron administradas sin que se presentaran reacciones colaterales adversas.
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Dawes, R.F.H., Royle, G.T., Dennison, A.R. et al. Metabolic studies of a lipid emulsion containing medium-chain triglyceride in perioperative and total parenteral nutrition infusions. World J. Surg. 10, 38–46 (1986). https://doi.org/10.1007/BF01656088
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DOI: https://doi.org/10.1007/BF01656088