Summary
Ten patients (two with normal, eight with impaired renal function) on their usual diet were treated with cefodizime (HR 221) for seven days. The dosage was 4 g/day, adapted to renal function as appropriate. Platelet function, plasma coagulation and vitamin K metabolism were investigated before and on day 7 of therapy. Platelet function and plasma coagulation remained unchanged, regardless of the size of the serum antibiotic trough levels, in both normal and impaired renal function. Vitamin K1 metabolism remained unaffected, since no increase in vitamin K1 2,3 epoxide in the circulation was observed during the therapy. Cefodizime (HR 221), a parenteral aminothiazole cephalosporin, does not affect hemostasis.
Zusammenfassung
Zehn Patienten (zwei mit normaler, acht mit eingeschränkter Nierenfunktion) wurden sieben Tage mit Cefodizim (HR 221), einem parenteralen Aminothiazol-Cephalosporin, behandelt. Die Dosierung wurde der Nierenfunktion angepaßt. Thrombozytenzahl, Thrombozytenfunktion und Blutungszeit, plasmatische Gerinnung und Vitamin-K-Metabolismus wurden vor und am Tag 7 der Therapie mit Cefodizim untersucht. Unabhängig von den Antibiotikaspiegeln blieb die Hämostase bei Patienten mit normaler und eingeschränkter Nierenfunktion unbeeinflußt. Weder Plättchenfunktion noch plasmatische Gerinnung änderten sich signifikant. Der Vitamin-K-Metabolismus wurde nicht beeinträchtigt.
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Andrassy, K., Koderisch, J., Trenk, D. et al. Hemostasis in patients with normal and impaired renal function under treatment with cefodizime. Infection 15, 348–350 (1987). https://doi.org/10.1007/BF01647736
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DOI: https://doi.org/10.1007/BF01647736