Abstract
Anti-Hu autoantibodies in high titres, as revealed with immunocytochemistry and Western blot, were present in a patient with gastrointestinal pseudoobstruction and small-cell lung cancer (SCLC) bearing the Hu antigen. Marked neuron and nerve fibre loss were found in the myenteric plexus at postmortem. These findings show that neuronopathic Hu-associated gastrointestinal pseudo-obstruction can occur as the only paraneoplastic neurological symptom in patients with SCLC.
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Ahmed MN, Carpenter S (1975) Autonomic neuropathy and carcinoma of the lung. CMA Journal 6:410–412
Altermatt HJ, Rodriguez M, Scheithauer BW, Lennon VA (1991) Paraneoplastic anti-Purkinje and type I anti-neuronal autoantibodies bind selectively to central, peripheral, and autonomic nervous system cells. Lab Invest 65:412–420
Camilleri M, Malagelada JR, Stanghellini V, Fealey RD, Sheps SC (1985) Gastrointestinal motility disturbances in patients with orthostatic hypotension. Gastroenterology 88:1852–1859
Chinn JS, Schuffler MD (1988) Paraneoplastic visceral neuropathy as a cause of severe gastrointestinal motor dysfunction. Gastroenterology 95:1279–1286
Dalmau J, Furneaux H, Gralla R, Kris M, Posner J (1990) Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer-a quantitative Western blot analysis. Ann Neurol 27:544–552
Dalmau J, Furneaux HM, Cordon-Cardo C, Posner JB (1992a). The expression of the Hu (paraneoplastic encephalomyelitis/ sensory neuronopathy) antigen in human normal and tumor tissues. Am J Pathol 141:881–886
Dalmau J, Graus F, Rosenblum MK, Posner JB (1992b) Anti-Huassociated paraneoplastic encephalomyelitis/sensory neuronopathy. A clinical study of 71 patients. Medicine 71:59–72
Darnell RB, DeAngelis LM (1993) Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies. Lancet 341:21–22
Graus F, Dalmau J (1991) Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma. Gastroenterology 101:1142–1143
Graus F, Cordon-Cardo C, Posner JB (1985) Neuronal antinuclear antibodiy in sensory neuronopathy from lung cancer. Neurology 35:538–543
Graus F, Ribalta T, Campo E, Monforte R, Urbano A, Rozman C (1990) Immunohistochemical analysis of the immunoreaction in the nervous system in paraneoplastic encephalomyelitis. Neurology 40:219–222
Lennon VA, Sas DF, Busk MF, Scheithauer B, Malagelada JR, Camilleri M, Miller LJ (1991) Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma. Gastroenterology 100:137–142
Lhermitte F, Gray F, Lyon-Caen O, Pertuiset BF, Bernard P (1980) Paralysie du tube digestif avec lésions de plexus myentériques. Nouveau syndrome paranéoplasique possible. Rev Neurol(Paris) 136:825–836
Schuffler MD, Baird HW, Fleming R, Bell CE, Bouldin TW, Malagelada JR, McGill DB, LeBauer S, Abrams M, Love J (1983) Intestinal pseudo-obstruction as the presenting manifestation of small-cell carcinoma of the lung. Ann Int Med 98:129–134
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Condom, E., Vidal, A., Rota, R. et al. Paraneoplastic intestinal pseudo-obstruction associated with high titres of Hu autoantibodies. Vichows Archiv A Pathol Anat 423, 507–511 (1993). https://doi.org/10.1007/BF01606543
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DOI: https://doi.org/10.1007/BF01606543