Summary
Supplementing the culture ofMicromonospora chersina sp. nov. No. M956-1 with NaI (0.5 mg/l) enhanced the production of dynemicin A by 35-fold in shake flask culture. Homogeneous dynemicin A was obtained from the whole broth extract by Dicalite chromatography, Sephadex LH-20 chromatography and vacuum liquid chromatography. Gram quantities of dynemicin A were obtained from the fermentation ofM. chersina sp. nov. No. M956-1 in a 10000-liter fermentor.
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Lam, K.S., Titus, J.A., Dabrah, T.T. et al. Improved processes for the production and isolation of dynemicin A and large-scale fermentation in a 10000-liter fermentor. Journal of Industrial Microbiology 11, 7–12 (1992). https://doi.org/10.1007/BF01583725
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DOI: https://doi.org/10.1007/BF01583725