Summary
In Switzerland 278 diabetic men and 256 women in the age group 35 to 54 were examined for the presence of angiopathic lesions, according to a standardized protocol of a multinational study comprising 6,695 diabetics from 14 countries. The diabetics were distributed according to sex, age, and duration of the disease into groups of equal size.
Macro-angiopathy, as the sum of coronary heart disease, stroke, and vascular disease of the legs was found in 28% of men and in 29% of women in the Swiss group. The prevalence of myocardial infarction alone was 6.8% in men and 5.5% in women. These rates did not differ from those found in the other national groups. Micro-angiopathy was found in the form of retinopathy in 35% and as nephropathy in 32% of the Swiss diabetics. These rates were not different from those of all groups. Severe retinopathy was found more frequently in Swiss diabetics than in the whole study. Micro-angiopathy was strongly related to duration, hypertension, and type of treatment in all centres. Japanese diabetics showed a higher frequency of micro-angiopathy, although macrovascular disease was found at a low rate.
Systolic blood pressure (BP) in the Swiss diabetics did not differ from the results of the whole group. In 14% of the Swiss diabetic men and in 18% of the women, systolic BP was over 160 mmHg. These rates were remarkably higher than in an age- and sex-matched sample of a randomly selected sample of a Swiss population (3.2% in men, 2.4% in women). Cholesterol was high in the Swiss diabetic groups, whereas body mass index was in the intermediate range. Of the Swiss diabetic men 38% smoked regularly. The frequency of coronary heart disease in Swiss men and women was similar. This is different from the lower rate usually found in non-diabetic women.
Age, and not duration of the disease was the most important factor relating to macro-angiopathy. The different rates of macro- and microvascular complications in various populations, selected according to the same protocol, suggests that the risk factors for macrovascular disease differ from those of microvascular complications. Race, nutrition, treatment, exercise, and hypertension may further influence the prevalence of angiopathy in diabetics of same sex, age, and duration of the disease.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Literatur
Gutzwiler F, Hoffmann H, Alexander J, Brunner HR, Schucan C, Vetter W (1981) Epidemiologie des Blutdrucks in vier Schweizer Städten. Schweiz Med Wochenschr [Suppl 12]:40, 46
Janka HU, Grünwald P, Waldmann G, Standl E, Mehnert H (1982) Karotisstenosen, kardiovaskuläres Risikoprofil und assoziierte Makroangiopathie bei ambulanten Diabetiikern. Die Schwabinger Studie zur Makroangiopathie bei Diabetikern. Vasa II:111–116
Jarrett RJ, Keen H, Grabauskas V (1979a) The WHO multinational study of vascular disease in diabetes: 1. General description. Diabetes Care 2:175–186
Keen H, Jarrett RJ (1979 b) The WHO multinational study of vascular disease in diabetes: 2. Macrovascular disease prevalence. Diabetes Care 2:187–195
Jarrett RJ, Keen H (1979c) The WHO multinational study of vascular disease in diabetes: 3. Microvascular disease. Diabetes Care 2:196–201
Knowler WC, Bennett PH, Ballintine EJ (1980) Increased incidence of retinopathy in diabetics with elevated blood pressure. N Eng J Med 302:645
Rose GA, Blackburn H (1968) Cardiovascular survey methods, WHO Geneva. WHO Monograph Series No 56
West KM, Ahuya MMS, Bennett PH, Grab B, Grabauskas V, de Acosta OM, Fuller JH, Jarrett RJ, Keen H, Kosaka K, Krolewski AS, Miki E, Schliack V, Teuscher A (1982 a) Interrelationships of microangiopathy, blood glucose, and other risk factors in 3583 diabetics: A multinational study. Diabetologia 22, 6:412–420
West KM, Ahuya MMS, Bennett PH, Grab B, Grabauskas V, de Acosta OM, Fuller JH, Jarrett RJ, Keen H, Kosaka K, Krolewski AS, Miki E, Schliack V, Teuscher A (1982b) Relationship of macroangiopathy to blood glucose, triglyceride and other risk factors in diabetics of nine populations. Diabetics Care (im Druck)
World Health Organization (1982) Vascular disease in diabetics. Report of the multinational study of vascular disease in diabetics, based upon the Meeting of Investigators held in Bern, Switzerland, 3–8 September 1979
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Teuscher, A., Herman, J.B. & Studer, P.P. Vaskuläre Erkrankungen bei 534 Schweizer Diabetikern im Rahmen einer multinationalen Studie. Klin Wochenschr 61, 139–149 (1983). https://doi.org/10.1007/BF01486368
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01486368