Zusammenfassung
Thrombin und Faktor XIII stimulieren die Fibroblastenproliferation unter Gleichzeitiger intrazellulärer Zunahme von cGMP. Fibronectin hemmt dagegen die relative3H-Thymidin-Aufnahme von Fibroblasten. neuraminidase-Inkubation der Fibroblasten schaltet die Thrombinwirkung vollständig aus, die Faktor XIII-Wirkung wird zu höheren Konzentrationen hin verschoben. Es wird diskutiert, da\ Thrombin und Faktor XIII die Fibroblastenproliferation wie Gewebshormone stimulieren und zusammen mit dem hemmenden Fibronectin eine Regulation des Fibroblastenwachstums im Rahmen der Thrombusorganisation, der Wundheilung und des arteriosklerotischen Gefäßwandprozesees (Intimafibrose) bewirken.
Summary
The stimulation of fibroblast proliferation by thrombin and factor XIII is accompanied by an intracellular increase of cGMP. In contrast fibronectin inhibits the3H-thymidine uptake of fibroblasts. Pre-treatment of fibroblasts with neuraminidase eliminates the stimulating effect of thrombin completely and induces a shift of the optimum stimulating effect of factor XIII to higher concentrations. It is discussed that thrombin and factor XIII stimulate the proliferation of fibroblasts as growth hormones and regulate in combination with the inhibiting fibronectin the growth of fibroblasts in thrombus organization, would healing and in the arteriosclerotic vessel wall process.
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References
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Bruhn, H.D., Pohl, J. Growth regulation of fibroblasts by thrombin, factor XIII and fibronectin. Klin Wochenschr 59, 145–146 (1981). https://doi.org/10.1007/BF01477357
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DOI: https://doi.org/10.1007/BF01477357
Schlüsselwörter
- Thrombin
- Faktor XIII
- Fibronectin
- Gewebshormone
- Fibroblastenproliferation
- Thrombusorganisation
- Wundheilung
- Arteriosklerotischer Gefäßwandprozeß