Summary
Vascular glioblastomas become liquefied when contaminated with spores of the non-pathogenic Clostridium butyricum M 55. The spores are administered by intracarotid injection. The oncolysis is complete one week after injection. The glioblastoma is converted into a brain abscess which is then operated on appropriately. Forty nine patients have been treated in this manner. The rate of recurrence, however, remained uninfluenced.
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Heppner, F., Die Behandlung fortgeschrittener Malignome des Großhirns. Wien. klin. Wschr.78 (1966), 482.
Heppner, F., Grundlagenforschung und praktische Erfahrungen mit dem Clostridienstamm „M 55“. Internat. Kongreß für Chemotherapie, Wien, Juli 1967. S. 623.
Heppner, F., Möse, J. R., Onkolyse maligner Gliome durch apathogene Clostridien (Stamm „M 55“). Zbl. Neurochir.27 (1966), 183–192.
Heppner, F., Diemath, H. E., Combination of antimitotics and oncolysis in the treatment of malignant tumours of the brain. XI. Internat. Krebskongreß, Houston 1970, S. 427.
Kretschmer, H., Gläser, A., Gräßer, A., Die Behandlung maligner Geschwülste mit Sporen von Clostridium butyricum M 55, I, II und III. Arch. Geschwulstforsch.39 (1972), 185, 195 und 315.
Möse, J. R., Möse, G., Probst, A., Heppner, F., Onkolyse maligner Tumoren durch den Clostridienstamm „M 55“. Med. Klin.62 (1967), 189–193 und 220–225.
Probst, A., Möse, J. R., Die Wirkung apathogener Clostridien auf bösartige Tumoren. Z. Krebsforsch.68 (1966), 337–351.
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Heppner, F., Möse, J.R. The liquefaction (oncolysis) of malignant gliomas by a non pathogenic Clostridium. Acta neurochir 42, 123–125 (1978). https://doi.org/10.1007/BF01406639
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DOI: https://doi.org/10.1007/BF01406639