Abstract
The aim of this study was to compare the results obtained with an indium-111 scan with those obtained with less expensive and harmless ultrasonography to evaluate the location and inflammatory activity of Crohn's disease. Thirty-one patients previously studied with x-ray underwent abdominal111In scans and ultrasonography (US). Sensitivity and specificity of US in detecting lesions seen with111In scan were 77% and 92.8%, respectively. Sensitivity and specificity of111In scan in detecting x-ray-defined lesions were 69.2% and 92.7%; the figures for US were 73% and 93.3%, respectively. Considering the evaluation of disease activity, ultrasonographic bowel wall thickness was significantly related to scintigraphic intensity of emission (r=0.75 P<0.01). Our experience suggests that US provided information about the location and inflammatory activity of lesions similar to that obtained from111In scan.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Saverymuttu SH, Camilleri M, Rees H, Lavander JP, Hodgson HJF, Chadwick VS: Indium 111 granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. Gastroenterology 90:1121–1128, 1986
Saverymuttu SH, Peters AM, Lavander JP, Peyps MB, Hodgson HJF, Chadwick VS: Quantitative fecal indium 111 labeled leukocyte excretion in the assessment of disease in Crohn's disease, Gastroenterology 85:1333–1339, 1983
Holt S, Samuel E: Grey scale ultrasound in Crohn's disease. Gut 20:590–595, 1979
Sonnenberg A, Erckenbrecht J, Peter P, Niederau C: Detection of Crohn's disease by ultrasound. Gastroenterology 83:430–434, 1982
Dubbins PA: Ultrasound demonstration of bowel wall scan thickness in inflammatory bowel disease. Clin Radiol 35:227–231, 1984
Khaw KT, Saverymuttu SH, Joseph AEA: Correlation of 111 indium WBC scintigraphy with ultrasound in the detection and assessment of inflammatory bowel disease. Clin Radiol 42(6):410–413, 1990
Best WR, Becktel JM, Singleton JW, Kern F Jr: Development of a Crohn's disease activity index. National cooperative Crohn's disease study. Gastroenterology 70:439–444, 1976
Thakur ML, Lavender JP, Arnot RN, Silvester DJ, Segal AW: Indium-111-labeled autologous leukocytes in man. J Nucl Med 18:1012–1019, 1977
Worlicek H, Lutz H, Heyder N, et al: Ultrasound findings in Crohn's disease and ulcerative colitis: A prospective study. J Clin Ultrasound 15:153–163, 1987
Kimmey MB, Martin RW, Haggitt RC, et al: Histologic correlates of gastrointestinal ultrasound images. Gastroenterology 96:433–441, 1989
Slaton GD, Navab F, Boyd CM, Diner WC, Texter EC: Role of delayed Indium 111 labeled leucocyte scan in the management of Crohn's disease. Am J Gastroenterol 80:790–795, 1985
Saverymuttu SH: Clinical remission in Crohn's disease. Assessment using fecal 111 in granulocyte excretion. Digestion 33:74–79, 1986
Pullman WE, Sullivan PJ, Barratt PJ, Lising J, Booth JA, Doe WF: Assessment of inflammatory bowel disease activity by technetium 99-m phagocyte scanning. Gastroenterology 95:989–996, 1988
Pederson BH, Gronwall S, Dorph S, Fahrenkrug L, Holm HH, Binder V: The value of dynamic ultrasound scanning in Crohn's disease. Scand J Gastroenterol 21:969–972, 1986
Crama-Bohbouth G, Pena AS, Biemond I, Vespaget HW, Blok D, Arndt JW, Weterman IT, Pawels EKJ, Lamers ABHW: Are activity indices helpful in assessing active intestinal inflammation in Crohn's disease? Gut 30:1236–1240, 1989
Park RHR, McKillop JH, Duncan A, MacKenzie JF, Russel RI: Can 111 indium autologous mixed leukocyte scanning accurately assess disease extent and activity in Crohn's disease? Gut 29:821–825, 1988
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Brignola, C., Belloli, C., Iannone, P. et al. Comparison of scintigraphy with indium-111 leukocyte scan and ultrasonography in assessment of x-ray-demonstrated lesions of crohn's disease. Digest Dis Sci 38, 433–437 (1993). https://doi.org/10.1007/BF01316495
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01316495