Summary
A 28-year-old woman who complained of mild abdominal pain was found to have a large liver tumor. Angiography and needle biopsy established the diagnosis of hepatocellular adenoma. The tumor was felt to be unresectable because of its size, and no treatment was given other than withdrawal of oral contraceptives. Subsequent hepatic scintiscans documented complete resolution of the tumor over a 12-month period.
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Rooks JB, Ory HW, Ishak KG, Strauss LT, Greenspan JR, Hill AP, Tyler CW, The Cooperative Live Tumor Group: Epidemiology of hepatocellular adenoma. The role of oral contraceptive use. J Am Med Assoc 242:644–648, 1979
Edmondson HA, Henderson B, Benton B: Liver-cell adenomas associated with use of oral contraceptives. N Engl J Med 294:470–472, 1976
Ishak KG: Hepatic neoplasms associated with contraceptive and anabolic steroids. Recent Results Cancer Res 66:73–128, 1979
Klatskin G: Hepatic tumors: Possible relationship to use of oral contraceptives. Gastroenterology 73:386–394, 1977
Christopherson WM, Mays ET: Liver tumors and contraceptive steroids: Experience with the first one hundred registry patients. J Natl Cancer Inst 58:167–170, 1977
Vana J, Murphy GP, Aronoff BL, Baker HW: Primary liver tumors and oral contraceptives. Results of a survey. J Am Med Assoc 238:2154–2158, 1977
Edmondson HA, Reynolds TB, Henderson B, Benton B: Regression of liver cell adenomas associated with oral contraceptives. Ann Intern Med 86:180–182, 1977
Andersen PH, Packer JT: Hepatic adenoma. Observations after estrogen withdrawal. Arch Surg 111:898–900, 1976
Ramseur WL, Cooper MR: Asymptomatic liver cell adenomas. Another case of resolution after discontinuation of oral contraceptive use. J Am Med Assoc 239:1647–1648, 1978
Kay S: Nine year follow-up of a case of benign liver cell adenoma related to oral contraceptives. Cancer 40:1759–1760, 1977
Benedict KT, Chen PS, Janower ML, Farmelant MH, Howard JT, McDermott W: Contraceptive associated hepatic tumor. Am J Roentgenol 132:452–454, 1979
Cornish PG: Liver cell adenoma. J Am Med Assoc 235:249, 1976
Galloway SJ, Cararella WJ, Lattes R, Seaman WB: Minimal deviation hepatoma: A new entity. Am J Roentgenol 125:184–192, 1975
Model DG, Fox JA, Jones RW: Multiple hepatic adenomas associated with an oral contraceptive. Lancet 1:865, 1975
Salvo AF, Schiller A, Athanasoulis C, Galdabini J, McKusick KA: Hepato-adenoma and focal nodular hyperplasia: Pitfalls in radiocolloid imaging. Radiology 125:451–455, 1977
Sackett J, Mosenthol W, House R, Geffery RF: Scintillation scanning of liver cell adenoma. Am J Roentgenol 113:56–60, 1971
Britton WJ, Gallagher ND, Little JM: Liver tumors associated with oral contraceptives. Med J Aust 2:223–227, 1978
Albritton DR, Tompkins RK, Longmire WP: Hepatic cell adenoma: A report of four cases. Ann Surg 180:14–19, 1974
Winkler K, Poulsen H: Liver disease with periportal sinusoidal dilatation. A possible complication to contraceptive steroids. Scand J Gastroenterol 10:699–704, 1975
Beaconsfield: Liver tumors and oral contraceptives. Lancet 1:516–517, 1974
Kaufman J-P, Miller DL, Gumucio JJ: Estrogen-induced zonal changes in hepatic sinusoids. Gastroenterology 78:1318, 1980
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Steinbrecher, U.P., Lisbona, R., Huang, S.N. et al. Complete regression of hepatocellular adenoma after withdrawal of oral contraceptives. Digest Dis Sci 26, 1045–1050 (1981). https://doi.org/10.1007/BF01314771
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DOI: https://doi.org/10.1007/BF01314771