Conclusion
The battle against RSV has been long and littered with setbacks and disappointments. Improvements in the management of infant bronchiolitis and pneumonia have reduced mortality but the virus remains a major cause of serious, distressing and, occasionally fatal, disease in the very young. Painstaking work in many hospitals and laboratories has built up a detailed picture of the virus and its epidemiology but its pathogenesis and prevention remain enigmatic. The stage is now set for dramatic advances against this important disease of man and animals in which the powerful new techniques in immunology and biotechnology must be the principal players.
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Ada, G. L., Leung, K.-N., Ertl, H.: An analysis of effector T cell generation and function in mice exposed to influenza A or Sendai viruses. Immunol. Rev.58, 5–24 (1981).
Aherne, W., Bird, T., Court, S. D. M., Gardner, P. S., McQuillin, J.: Pathological changes in virus infections of the lower respiratory tract in children. J. Clin. Path.23, 7–18 (1970).
Ana, P. P., Arrobio, J. O., Kim, H. W., Brandt, C. D., Chanock, R. M., Parrott, R. H.: Serum complement in acute bronchiolitis. Proc. Soc. Exp. Biol. Med.134, 499–503 (1970).
Armstrong, J. A., Pereira, H. G., Valentine, R. C.: Morphology and development of respiratory syncytial virus in cell cultures. Nature196, 1179–1181 (1962).
Bächi, T., Howe, C.: Morphogenesis and ultrastructure of respiratory syncytial virus. J. Virol.12, 1173–1180 (1973).
Baldridge, P., Senterfit, L. B.: Persistent infection of cells in culture by respiratory syncytial virus. Proc. Soc. exp. Biol. Med.151, 684–688 (1976).
Bancroft, G. J., Shellam, G. R., Chalmer, J. E.: Genetic influences on the augmentation of natural killer (NK) cells during murine cytomegalovirus infection: correlation with patterns of resistance. J. Immunol.126, 988–994 (1981).
Beem, M.: Repeated infections with respiratory syncytial virus. J. Immunol.98, 1115–1122 (1967).
Beem, M., Wright, F. H., Hamre, D., Egerer, R., Oehme, M.: Association of the chimpanzee coryza agent with acute respiratory disease in children. New Eng. J. Med.263, 523–530 (1960).
Bell, D. M., Roberts, N. J., Hall, C. B.: Different antiviral spectra of human macrophage interferon activities. Nature305, 319–321 (1983).
Belshe, R. B., Richardson, L. S., London, W. T., Sly, D. L., Lorfeld, J. H., Camargo, E., Prevar, D. A., Chanock, R. M.: Experimental respiratory syncytial virus infection of four species of primates. J. Med. Virol.1, 157–162 (1977).
Belshe, R. B., Richardson, L. S., London, W. T., Sly, D. L., Camargo, E., Prevar, D. A., Chanock, R. M.: Evaluation of five temperature sensitive mutants of respiratory syncytial virus in primates: II. Genetic analysis of virus recovered during infection. J. Med. Virol.3, 101–110 (1978).
Belshe, R. B., Richardson, L. S., Prevar, D. A., Camargo, E., Chanock, R. M.: Growth and genetic stability of 4 temperature sensitive (ts) mutants of respiratory syncytial (RS) virus in newborn ferrets. Arch. Virol.58, 313–321 (1978).
Belshe, R. B., van Voris, L. P., Mufson, M. A.: Parenteral administration of live respiratory syncytial virus vaccine: Results of a field trial. J. inf. Dis.145, 311–319 (1982).
Belshe, R. B., van Voris, L. P., Mufson, M. A., Buynak, E. B., McLean, A. A., Hilleman, M. A.: Comparison of enzyme-linked immunosorbent assay and neutralization techniques for measurement of antibody to respiratory syncytial virus: Implications for parenteral immunization with live virus vaccine. Infect. Immun.37, 160–165 (1982).
Bennett, C. R., Hamre, D.: Growth and serological characteristics of respiratory syncytial virus. J. inf. Dis.110, 8–16 (1962).
Berglund, B., Kortekangas, A. E., Lauren, P.: Experimental inoculation of guinea pigs middle ear with respiratory syncytial virus. Acta Otolaryngol. (Stockh.)224 (suppl.), 268–271 (1966).
Bernstein, J. M., Hruska, J. F.: Respiratory syncytial virus proteins identification by immunoprecipitation. J. Virol.38, 278–285 (1981).
Berthiaume, L., Joncas, J., Boulay, G., Pavilanis, V.: Serological evidence of respiratory syncytial virus infection in sheep. Vet. Rec.93, 337–338 (1973).
Berthiaume, L., Joncas, J., Pavilanis, V.: Comparative structure, morphogenesis and biological characteristics of the respiratory syncytial (RS) virus and the pneumonia virus of mice. Arch. ges. Virusforsch.45, 39–51 (1974).
Bertotto, A., Stagni, G., Caprino, D., Sonaglia, F., Velardi, A.: Cell-mediated immunity in RSV bronchiolitis. J. Pediat.97, 334–335 (1980).
Biron, C. A., Welsh, R. M.: Activation and roll of natural killer cells in virus infection. Med. Microbiol. Immunol.170, 155–172 (1982).
Bloth, B., Norrby, E.: Fractionation of respiratory syncytial virus components by centrifugation techniques. Arch. ges. Virusforsch.19, 385–392 (1966).
Brandt, C. D., Kim, H. W., Arrobio, J. O., Jeffries, B. C., Wood, S. C., Chanock, R. M., Parrott, R. H.: Epidemiology of respiratory syncytial virus infection in Washington, D.C. III. Composite analysis of eleven consecutive yearly epidemics. Am. J. Epidem.98, 355–364 (1973).
Brandt, C. D., Parrott, R. H., Patrick, J. R., Kim, H. W., Arrobio, J. O., Chandre, R., Jeffries, B. C., Chanock, R. M.: Epidemiology-sids and viral respiratory disease in metropolitan Washington, D.C. In:Robinson, R. R. (ed.), S.I.D.S. Proceedings of the Francis E. Camps International Symposium on Sudden and Unexpected Death in Infancy, 117–129. Canadian Foundation for the Study of Infant Death. 1974.
Bruhn, F. W., Yeager, A. S.: Respiratory syncytial virus in early infancy. Circulating antibody and the severity of infection. Am. J. Dis. Child.131, 145–148 (1977).
Bryson, D. G., McNulty, M. S., Logan, E. F., Cush, P. F.: Respiratory syncytial virus pneumonia in young calves: Clinical and pathologic findings. Am. J. Vet. Res.44, 1648–1655 (1983).
Bui, H. D., Imagawa, D. T., Heiner, D. C., St. Geme, J. W., Wright, P. F., Karzon, D. T.: A novel pathogenetic concept of wheezing in respiratory syncytial virus (RSV) bronchiolitis. Clin. Res.30, 128 A (1982).
Buynak, E. B., Weibel, R. E., Carlson, A. J., McLean, A. A., Hilleman, M. R.: Further investigations of live respiratory syncytial virus vaccine administered parenterally. Proc. Soc. exp. Biol. Med.160, 272–277 (1979).
Buynak, E. B., Weibel, R. E., McLean, A. A., Hilleman, M. R.: Live respiratory syncytial virus vaccine administered parenterally. Proc. Soc. exp. Biol. Med.157, 636–642 (1978).
Carfrae, D. C., Bell, E. J., Grist, N. R.: Fatal haemorrhagic pneumonia in an adult due to respiratory syncytial virus andStaphylococcus aureus. J. Infect.4, 79–80 (1982).
Casali, P., Oldstone, M. B. A.: Mechanisms of killing of measles virus-infected cells by human lymphocytes: Interferon associated and unassociated cell-mediated cytotoxicity. Cell Immunol.70, 330–344 (1982).
Casali, P., Sissons, J. G., Buchmeier, M. J., Oldstone, M. B. A.:In vitro generation of human cytotoxic lymphocytes by virus. Virol glycoproteins induce nonspecific cell-mediated cytotoxicity without release of interferon. J. Exp. Med.154, 840–855 (1981).
Cash, P., Pringle, C. R., Preston, C. M.: The polypeptides of human respiratory syncytial virus: products of cell-free protein synthesis and post-translational modifications. Virology92, 375–384 (1979).
Cash, P., Wunner, W. H., Pringle, C. R.: A comparison of the polypeptides of human and bovine respiratory syncytial viruses and murine pneumonia virus. Virology82, 369–379 (1977).
Cavallaro, J. J., Maassab, H. F.: Adaptation of respiratory syncytial (RS) virus to brain of suckling mice. Proc. Soc. Exp. Biol. Med.121, 37–41 (1966).
Cavallaro, J. J., Maassab, H. F., Abrams, G. D.: An immunofluorescent and histopathological study of respiratory syncytial (RS) virus encephalitis in suckling mice. Proc. Soc. Exp. Biol. Med.124, 1059–1064 (1967).
Chanock, R. M., Finberg, L.: Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). II. Epidemiologic aspects of infection in infants and young children. Amer. J. Hyg.66, 291–300 (1957).
Chanock, R. M., Kapikian, A. Z., Mills, J., Kim, H. W., Parrott, R. H.: Influence of immunological factors in respiratory syncytial virus disease. Arch. Environ. Hlth.21, 347–355 (1970).
Chanock, R. M., Kim, H. W., Brandt, C. Parrott, R. H.: Respiratory syncytial virus. In:Evans, A. S. (ed.), Viral Infections of Humans. Epidemiology and Control, 365–382. Plenum. 1976.
Chanock, R. M., Parrott, R. H.: Acute respiratory disease in infancy and childhood: present understanding and prospects for prevention. Pediat.36, 21–39 (1965).
Chanock, R. M., Roizman, B., Myers, R.: Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). I. Isolation, properties and characterisation. Amer. J. Hyg.66, 281–290 (1957).
Chapes, K. S., Tompkins, W. F.: Cytotoxic macrophages induced in hamsters by vaccinia virus: selective cytotoxicity for virus-infected targets by macrophages collected late after immunization. J. Immunol.123, 303–310 (1979).
Chin, J., Magoffin, R. L., Shearer, L. A., Schieble, J. H., Lennette, E. H.: Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Amer. J. Epid.89, 449–463 (1969).
Coates, H. W., Alling, D. W., Chanock, R. M.: An antigenic analysis of respiratory syncytial virus isolation by a plaque reduction neutralisation test. Amer. J. Epid.83, 299–313 (1966).
Coates, H. V., Chanock, R. M.: Experimental infection with respiratory syncytial virus in several species of animals. Am. J. Hyg.76, 302–312 (1962).
Coates, H. V., Forsyth, B. R., Chanock, R. M.: Biophysical studies of respiratory syncytial virus. I. Density of respiratory syncytial virus and associated complement-fixing antigens in a caesium chloride density gradient. J. Bact.91, 1263–1269 (1966).
Coates, H. V., Kendrick, L., Chanock, R. M.: Antigenic differences between two strains of respiratory syncytial virus. Proc. Soc. exp. Biol. Med.112, 958–964 (1963).
Collier, A. M., Clyde, W. A.: Model systems for studying the pathogenesis of infections causing bronchiolitis in man. Pediat. Res.11, 243–246 (1977).
Collins, P. L., Huang, Y. T., Wertz, G. W.: Identification of a tenth mRNA of respiratory syncytial virus and assignment of polypeptides to the 10 viral genes. J. Virol.49, 572–578 (1984).
Communicable Disease Service Centre: Respiratory syncytial virus activity in the United Kingdom, 1979. J. Infect.2, 93–97 (1980).
Cooney, M. K., Fox, J. P., Hall, C. E.: The Seattle virus watch. VI. Observations of infections with and illness due to parainfluenza, mumps and respiratory syncytial viruses andMycoplasma pneumoniae. Am. J. Epid.101, 532–551 (1975).
Corbitt, G.: Interferon and respiratory syncytial virus. Lancet2, 492–493 (1971).
Cote, P. J., Fernie, B. F., Ford, E. C., Shih, J. W. K., Gerin, J. L.: Monoclonal antibodies to respiratory syncytial virus: detection of virus neutralization and other antigen-antibody systems using infected human and murine cells. J. Virol. Meth.3, 137–147 (1981).
Craft, A. W., Reid, M. M., Gardner, P. S., Jackson, E., Kernahan, J., McQuillin, J., Noble, T. C., Walker, W.: Virus infections in children with acute lymphoblastic leukaemia. Arch. Dis. Child.54, 755–759 (1979).
Cranage, M. P., Gardner, P. S.: Systemic cell-mediated and antibody responses in infants with respiratory syncytial virus infections. J. Med. Virol.5, 161–170 (1980).
Cranage, M. P., Gardner, P. S., McIntosh, K.:In vitro cell-dependent lysis of respiratory syncytial virus-infected cells mediated by antibody from local respiratory secretions. Clin. exp. Immunol.43, 28–35 (1981).
Crane, L. R., Kish, J. A., Ratanathorathorn, V., Merline, J. R., Raval, M. F. T.: Fatal syncytial virus pneumonia in a laminar airflow room. J. Am. med. Ass.246, 366–368 (1981).
Cutlip, R. C., Lehmkuhl, H. D.: Lesions in lambs experimentally infected with bovine respiratory syncytial virus. Am. J. Vet. Res.40, 1479–1482 (1979).
Delforge, J. L., Zygraich, N.: Evaluation clinique d'un vaccin vivant attènué pour l'immunisation des bovins contre le virus respiratoire syncytial. Ann. Méd. Vét.122, 545–554 (1978).
Doggett, J. E.: Antibodies to respiratory syncytial virus in human sera from different regions of the world. Bull. Wld. Hlth. Org.32, 849–853 (1965).
Doggett, J. E., Taylor-Robinson, D.: Serological studies with respiratory syncytial virus. Arch. ges. Virusforsch.15, 601–608 (1965).
Doggett, J. E., Taylor-Robinson, D., Gallop, R. G. C.: A study of an inhibitor in bovine serum active against respiratory syncytial virus. Arch. ges. Virusforsch.23, 126–137 (1968).
Downham, M. A. P. S., Gardner, P. S., McQuillin, J., Ferris, J. A.: Role of respiratory viruses in childhood mortality. Brit. med. J.1, 235–239 (1975).
Downham, M. A. P. S., Scott, R., Sims, D. G., Webb, J. K. G., Gardner, P. S.: Breast-feeding protects against respiratory syncytial virus infections. Brit. Med. J.2, 274–276 (1976).
Dreizin, R. S., Vyshnevetskaya, L. O., Bagdamyan, E. E., Yankevich, O. D., Tarasova, L. B., Klenova, A. V.: Study of experimental RS virus infection in cotton rats. Virologic and immunofluorescent studies. Vopr. Virusol.16, 670–676 (1971).
Dubovi, E. J.: Analysis of proteins synthesized in respiratory syncytial virus-infected cells. J. Virol.42, 372–378 (1982).
Dubovi, E. J., Geratz, J. D., Shaver, S. R., Tidwell, R. R.: Inhibition of respiratory syncytial virus-host cell interactions by mono- and diamidines. Antimicrob. Ag. Chemother.19, 649–656 (1981).
Dubovi, E. J., Geratz, J. D., Tidwell, R. R.: Inhibition of respiratory syncytial virus by BIS (5-amidino-2-benzimidazolyl) methane. Virology103, 502–504 (1980).
Dubovi, E. J., Geratz, J. D., Tidwell, R. R.: Enhancement of respiratory syncytial virus-induced cytopathology by trypsin, thrombin and plasmin. Infect. Immun.40, 351–358 (1983).
Elango, N., Venkatesan, S.: Amino acid sequence of human respiratory syncytial virus nucleocapsid protein. Nucleic acids Res.11, 5941–5951 (1983).
Ertl, H. C. J.: Adoptive transfer of delayed-type hypersensitivity to sendai virus. I. Induction of two different subsets of T lymphocytes which differ in H-2 restriction as well as in the Lyt phenotype. Cell. Immun.62, 38–49 (1981).
Faden, H., Kaul, T. N., Ogra, P. L.: Activation of oxidative and arachidonic acid metabolism in neutrophils by respiratory syncytial virus antibody complexes: possible role in disease. J. Inf. Dis.148, 110–116 (1983).
Fernald, G. W., Almond, J. R., Henderson, F. W.: Cellular and humoral immunity in recurrent respiratory syncytial virus infections. Ped. Res.17, 753–758 (1983).
Fernie, B. F., Cote, P. J., Gerin, J. L.: Classification of hybridomas to respiratory syncytial virus glycoproteins. Proc. Soc. exp. Biol. Med.171, 266–271 (1982).
Fernie, B. F., Ford, E. C., Gerin, J. L.: The development of Balb/c cells persistently infected with respiratory syncytial virus: Presence of ribonucleo-protein on the cell surface. Proc. Soc. exp. Biol. Med.167, 83–86 (1981).
Fernie, B. F., Gerin, J. L.: The stabilization and purification of respiratory syncytial virus using MgSO4. Virology106, 141–144 (1980).
Fernie, B. F., Gerin, J. L.: Immunochemical identification of viral and nonviral proteins of the respiratory syncytial virus virion. Infect. Immun.37, 243–249 (1982).
Fishaut, M., Tubergen, D., McIntosh, K.: Cellular response to respiratory viruses with particular reference to children with disorders of cell-mediated immunity. J. Ped.96, 179–186 (1980).
Forsyth, B. R.: Identification of respiratory syncytial virus antigens by agar gel diffusion and immunoelectrophoresis. Proc. Soc. exp. Biol. Med.133, 568–572 (1970).
Forsyth, B. R., Coates, H. V., Chanock, R. M.: Biophysical studies of respiratory syncytial virus. II. Identification of two soluble complement-fixing antigens of respiratory syncytial virus. J. Bact.91, 1270–1276 (1966).
Frank, A. L., Taber, L. H., Glezen, W. P., Kasel, G. L., Wells, C. R., Paredes, A.: Breast feeding and respiratory syncytial virus infection. Pediatrics70, 239–245 (1982).
Fransen, H., Sterner, G., Forsgren, M.: Acute lower respiratory illness in elderly patients with respiratory syncytial virus infection. Acta Med. Scand.182, 323–330 (1967).
Friedewald, W. T., Forsyth, B. R., Smith, C. B., Gharpure, M. A., Chanock, R. M.: Low-temperature-grown RS virus in adult volunteers. J. Amer. med. Ass.204, 690–694 (1968).
Fulginiti, V. A., Eller, J. J., Sieber, O. F., Joyner, J. W., Minamitani, M., Meiklejohn, G.: Respiratory virus immunization. I. A field trial of two in-activated respiratory virus vaccines; an aqueous trivalent parainfluenza virus vaccine and an alum-precipitated respiratory syncytial virus vaccine. Amer. J. Epid.89, 435–448 (1969).
Gardner, P. S., Court, S. D. M., Brocklebank, J. T., Downham, M. A. P. S., Weightman, D.: Virus cross-infection in paediatric wards. Br. med. J.2, 571–575 (1973).
Gardner, P. S., McGuckin, R., Beale, A. J., Fernandes, R.: Interferon and respiratory syncytial virus. Lancet1, 574–575 (1970).
Gardner, P. S., McQuillin, J.: The coating of respiratory syncytial (RS) virus-infected cells in the respiratory tract by immunoglobulins. J. Med. Virol.2, 165–173 (1978).
Gardner, P. S., McQuillin, J., Court, S. D. M.: Speculation on pathogenesis in death from respiratory syncytial virus infection. Br. Med. J.1, 327–330 (1970).
Gardner, P. S., Turk, D. C., Aherne, W. A., Bird, T., Holdaway, M. D., Court, S. D. M.: Deaths associated with respiratory tract infection in childhood. Br. Med. J.4, 316–320 (1967).
Garvie, D. G., Gray, J.: Outbreak of respiratory syncytial virus infection in the elderly. Br. med. J.281, 1253–1254 (1980).
Gharpure, M. A., Wright, P. F., Chanock, R. M.: Temperature-sensitive mutants of respiratory syncytial virus. J. Virol.3, 414–421 (1969).
Glezen, W. P.: Pathogenesis of bronchiolitis: epidemiologic considerations. Pediat. Res.11, 239–243 (1977).
Glezen, W. P., Denny, F. W.: Epidemiology of acute lower respiratory disease in children. New Eng. J. Med.288, 498–505 (1973).
Glezen, W. P., Paredes, A., Allison, J. E., Taber, L. H., Frank, A. L.: Risk of respiratory syncytial virus infection for infants from low income families in relationship to age, sex, ethnic group, and maternal antibody level. J. Ped.98, 708–715 (1981).
Grist, N. R., Ross, C. A. C., Stott, E. J.: Influenza, respiratory syncytial virus and pneumonia in Glasgow 1962–1965. Br. Med. J.1, 456–457 (1967).
Hall, C. B.: Prevention of infections with respiratory syncytial virus: The hopes and hurdles ahead. Rev. Inf. Dis.2, 384–392 (1980).
Hall, C. B.: The nosocomial spread of respiratory syncytial viral infections. Ann. Rev. Med.34, 311–319 (1983).
Hall, C. B., Douglas, R. G.: Modes of transmission of respiratory syncytial virus. J. Pediat.99, 100–103 (1981).
Hall, C. B., Douglas, R. G., Geiman, J. M.: Respiratory syncytial virus infections in infants: quantitation and duration of shedding. J. Pediat.89, 11–15 (1976).
Hall, C. B., Douglas, R. G., Geiman, J. M.: Possible transmission by fomites of respiratory syncytial virus. J. Inf. Dis.141, 98–102 (1980).
Hall, C. B., Douglas, R. G., Geiman, J. M., Messner, M. K.: Nosocomial respiratory syncytial virus infections. New Eng. J. Med.293, 1343–1346 (1975).
Hall, C. B., Douglas, R. G., Schnabel, K. C., Geiman, J. M.: Infectivity of respiratory syncytial virus by various routes of inoculation. Infect. Immun.33, 779–783 (1981).
Hall, C. B., Douglas, R. G., Simons, R. L., Geiman, J. M.: Interferon production in children with respiratory syncytial, influenza, and parainfluenza virus infections. J. Pediat.93, 28–32 (1978).
Hall, C. B., Geiman, J. M., Biggar, R., Kotok, D., Hogan, P., Douglas, R. G.: Respiratory syncytial virus infections within families. New Eng. J. Med.294, 414–419 (1976).
Hall, W. J., Hall, C. B., Speers, D. M.: Respiratory syncytial virus infection in adults: Clinical, virologic, and serial pulmonary function studies. Ann. Intern. Med.88, 203–205 (1978).
Hall, C. B., Kopelman, A. E., Douglas, R. G., Geiman, J. M., Meagher, M. P.: Neonatal respiratory syncytial virus infection. New Eng. J. Med.300, 393–396 (1979).
Hall, C. B., McBride, J. T., Walsh, E. E., Bell, D. M., Gala, C. L., Hildreth, S., Ten Eyck, L. G., Hall, W. J.: Aerosolized ribavirin treatment of infants with respiratory syncytial viral infection. New Eng. J. Med.308, 1443–1447 (1983).
Hall, C. B., MacDonald, N. E., Klemperer, M. R., Ettinger, L. J.: Respiratory syncytial virus in immunocompromised children. Pediatr. Res.15, 613 (1981).
Hall, C. B., Walsh, E. E., Hruska, J. F., Betts, R. F., Hall, W. J.: Ribavirin treatment of experimental respiratory syncytial viral infection. J. Amer. Med. Ass.249, 2666–2670 (1983).
Halstead, S. B., O'Rourke, E. J.: Antibody-enhanced dengue virus infection in primate leukocytes. Nature265, 739–741 (1977).
Hambling, M. H.: Survival of respiratory syncytial virus during storage under various conditions. Brit. J. exp. Path.45, 647–655 (1964).
Hambling, M. H.: Antibody response in guinea-pigs following intranasal inoculation of respiratory syncytial virus. J. Path. Bact.91, 625–629 (1966).
Henderson, F. W., Collier, A. M., Clyde, W. A., Denny, F. W.: Respiratory syncytial virus infections, reinfections and immunity. New Eng. J. Med.300, 530–534 (1979).
Henry, R. L., Hodges, I. G. C., Milner, A. D., Stokes, G. M.: Respiratory problems 2 years after acute bronchiolitis in infancy. Arch. Dis. Child.58, 713–716 (1983).
Hierholzer, J. C., Hirsch, M. S.: Croup and pneumonia in human infants associated with a new strain of RSV. J. Inf. Dis.140, 826–828 (1979).
Hill, D. A., Baron, S., Chanock, R. M.: Sensitivity of common respiratory viruses to an interferon inducer in human cells. Lancet2, 187–188 (1969).
Hodes, D. S., Schnitzer, T. J., Kalica, A. R., Camargo, E., Chanock, R. M.: Inhibition of respiratory syncytial, parainfluenza 3 and measles viruses by 2-Deoxy-D-glucose. Virology63, 201–208 (1975).
Holzel, A., Parker, L., Patterson, W. H., Cartmel, D., White, L. L. R., Purdy, R., Thompson, K. M., Tobin, J. O'H.: Virus isolations from throats of children admitted to hospital with respiratory and other diseases, Manchester, 1962–1964. Br. Med. J.1, 614–619 (1965).
Holzhauer, C., Van Nieuwstadt, A. P.: De etiologischi rol van het bovine respiratory syncytial virus bij pinkengriep. Tijdschr. Diergeneoskd.101, 1023–1031 (1976).
Horn, M. E. C., Brain, E., Gregg, I., Yealland, S. J., Inglis, J. M.: Respiratory viral infection in childhood. A survey in general practice. Roehampton 1967–1972. J. Hyg.74, 157–168 (1975).
Howatson, A. F., Fornasier, V. L.: Microfilaments associated with Paget's disease of bone: Comparison with nucleo-capsids of measles virus and respiratory syncytial virus. Intervirol.18, 150–159 (1982).
Hruska, J. F., Bernstein, J. M., Douglas, R. G., Hall, C. B.: Effects of ribavirin on respiratory syncytial virusin vitro. Antimicrob. Agents Chemother.17, 770–775 (1980).
Hruska, J. F., Morrow, P. E., Suffin, S. C., Douglas, R. G.:In vivo inhibition of respiratory syncytial virus by ribavirin. Antimicrob. Agents Chemother.21, 125–130 (1982).
Huang, Y. T., Wertz, G. W.: The genome of respiratory syncytial virus is a negative stranded RNA that codes for at least seven mRNA species. J. Virol.43, 150–157 (1982).
Huang, Y. T., Wertz, G. W.: Respiratory syncytial virus mRNA coding assignments. J. Virol.46, 667–672 (1983).
Ida, S., Hooks, J. J., Siraganian, R. P., Notkins, A. L.: Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. J. Exp. Med.145, 892–906 (1977).
Inaba, Y., Tanaka, Y., Omori, T., Matumoto, M.: Physicochemical properties of bovine respiratory syncytial virus. Jap. J. Microbiol.17, 211–216 (1973).
Inaba, Y., Tanaka, Y., Sato, K., Omori, T., Matumoto, M.: Bovine respiratory syncytial virus. Studies on an outbreak in Japan 1968–1969. Jap. J. Microbiol.16, 373–383 (1972).
Ito, Y., Tanaka, Y., Inaba, Y., Omori, T.: Structure of bovine respiratory syncytial virus. Arch. ges. Virusforsch.40, 198–204 (1973).
Jacobs, J. W.: Immunity to infections of the respiratory system in man and animals. Develop. Biol. Standard.28, 609–616 (1975).
Johnson, K. M., Chanock, R. M., Rifkind, D., Kravetz, H. M., Knight, V.: Respiratory syncytial virus. IV. Correlation of virus shedding, serologic response, and illness in adult volunteers. J. Amer. Med. Ass.176, 663–667 (1961).
Johnson, R. A., Prince, G. A., Suffin, S. C., Horswood, R. L., Chanock, R. M.: Respiratory syncytial virus infection in cyclophosphamide-treated cotton rats. Infect. Immun.37, 369–373 (1982).
Joncas, J., Berthiaume, L., Pavilanis, V.: The structure of respiratory syncytial virus. Virology38, 493–496 (1969).
de Jong, J. C., Harmsen, M.: Stimulated growth of respiratory syncytial virus in the presence of actinomycin D. Antonie van Leeuwenhoek J. Microbiol. Serol.39, 409–413 (1973).
Jordan, W. S.: Growth characteristics of respiratory syncytial virus. J. Immunol.88, 581–590 (1962).
Kalica, A. R., Wright, P. F., Hetrick, F. M., Chanock, R. M.: Electron microscopic studies of respiratory syncytial virus temperature-sensitive mutants. Arch. ges. Virusforsch.41, 248–258 (1973).
Kapikian, A. Z., Mitchell, R. H., Chanock, R. M., Shvedoff, R. A., Stewart, C. E.: An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS vaccine. Amer. J. Epid.89, 405–421 (1969).
Kasupski, G. J., Leers, W.-D.: Presumed respiratory syncytial virus pneumonia in three immunocompromised adults. Am. J. Med. Sci.285, 28–33 (1983).
Kaul, T. N., Faden, H., Baker, R., Ogra, P. L.: Virus-induced complement activation and neutrophil-mediated cytotoxicity against respiratory syncytial virus (RSV). Clin. Exp. Immunol.56, 501–508 (1984).
Kaul, T. N., Faden, H. S., Middleton, E., Fugitani, T., Ogra, P. L.: Release of pharmacological mediators from human neutrophils by viral immune complexes: effects on mucosal smooth muscle function and possible role in clinical disease. Pediatr. Res.16, 224A, abst. no. 875 (1982).
Kaul, T. N., Welliver, R. C., Ogra, P. L.: Appearance of complement components and immunoglobulins on nasopharyngeal epithelial cells following naturally acquired infection with respiratory syncytial virus. J. med. Virol.9, 149–158 (1982).
Kaul, T. N., Welliver, R. C., Ogra, P. L.: Development of antibody-dependent cell-mediated cytotoxicity in the respiratory tract after natural infection with respiratory syncytial virus. Infect. Immun.37, 492–498 (1982).
Kim, H. W., Arrobio, J. O., Brandt, C. D., Jeferies, B. C., Pyles, G., Reid, J. L., Chanock, R. M., Parrott, R. H.: Epidemiology of respiratory syncytial virus infection in Washington, D.C. I. Importance of the virus in different respiratory tract disease syndromes and temporal distribution of infection. Amer. J. Epid.98, 216–225 (1973).
Kim, H. W., Arrobio, J., Brandt, C. D., Wright, P., Hodes, D., Chanock, R. M., Parrott, R. H.: Safety and antigenicity of temperature sensitive (TS) mutant respiratory syncytial virus (RSV) in infants and children. Pediat.52, 56–63 (1973).
Kim, H. W., Arrobio, J. O., Pyles, G., Brandt, C. D., Camargo, E., Chanock, R. M., Parrott, R. H.: Clinical and immunological response of infants and children to administration of low-temperature adapted respiratory syncytial virus. Pediat.48, 745–755 (1971).
Kim, H. W., Bellanti, J. A., Arrobio, J. O., Mills, J., Brandt, C. D., Chanock, R. M., Parrott, R. H.: Respiratory syncytial virus neutralizing activity in nasal secretions following natural infection. Proc. Soc. Exp. Biol. Med.131, 658–661 (1969).
Kim, H. W., Canchola, J. G., Brandt, C. D., Pyles, G., Chanock, R. M., Jensen, K., Parrott, R. H.: Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Amer. J. Epidem.89, 422–434 (1969).
Kim, H. W., Leikin, S. L., Arrobio, J., Brandt, C. D., Chanock, R. M., Parrott, R. H.: Cell-mediated immunity to respiratory syncytial virus induced by inactivated vaccine or by infection. Pediat. Res.10, 75–78 (1976).
Kimball, A. M., Foy, H. M., Cooney, M. K., Allan, I. D., Matlock, M., Plorde, J. J.: Isolation of respiratory syncytial and influenza viruses from the sputum of patients hospitalized with pneumonia. J. Inf. Dis.147, 181–184 (1983).
Kingsbury, D. W., Bratt, M. A., Choppin, P. W., Hanson, R. P., Hosaka, Y., ter Meulen, V., Norrby, E., Plowright, W., Rott, R., Wunner, W. H.: Paramyxoviridae. Intervirology10, 137–152 (1978).
Koff, W. C., Caplan, F. R., Case, S., Halstead, S. B.: Cell-mediated immune response to respiratory syncytial virus infection in owl monkeys. Clin. Exp. Immunol.53, 272–280 (1983).
Kravetz, H. M., Knight, V., Chanock, R. M., Morris, J. A., Johnson, K. M., Rifkind, D., Utz, J. P.: Respiratory syncytial virus III. Production of illness and clinical observations in adult volunteers. J. Amer. Med. Ass.176, 657–663 (1961).
Lagace-Simard, J., Descoteaux, J. P., Lussier, G.: Experimental pneumovirus infections. 2. Hydrocephalus of hamsters and mice due to infection with human respiratory syncytial virus (RS). Am. J. Pathol.107, 36–40 (1982).
Laing, I., Friedel, F., Yap, P. L., Simpson, H.: Atopy predisposing to acute bronchiolitis during an epidemic of respiratory syncytial virus. Br. Med. J.284, 1070–1072 (1982).
Lambert, D. M., Pons, M. W.: Respiratory syncytial virus glycoproteins. Virology130, 204–214 (1983).
Lambert, D. M., Pons, M. W., Mbuy, G. N., Dorsch-Hasler, K.: Nucleic acids of respiratory syncytial virus. J. Virol.36, 837–846 (1980).
Lamprecht, C. L., Krause, H. E., Mufson, M. A.: Role of maternal antibody in pneumonia and bronchiolitis due to respiratory syncytial virus. J. Inf. Dis.134, 211–217 (1976).
Lehmkuhl, H. D., Cutlip, R. C.: Experimentally induced respiratory syncytial virus infection in lambs. Am. J. Vet. Res.40, 512–514 (1979).
Lehmkuhl, H. D., Smith, M. H., Cutlip, R. C.: Morphogenesis and structure of caprine respiratory syncytial virus. Arch. Virol.65, 269–276 (1980).
Leung, K. N., Ashman, R. B., Ertl, H., Ada, G. L.: Selective suppression of the cytotoxic T cell response to influenza virus in mice. Eur. J. Immunol.10, 803–810 (1980).
Levine, S.: Polypeptides of respiratory syncytial virus. J. Virol.21, 427–431 (1977).
Levine, S., Buthala, D., Hamilton, R.: Late stage synchronization of respiratory syncytial virus replication. Virology45, 390–400 (1971).
Levine, S., Hamilton, R.: Kinetics of respiratory syncytial virus growth cycle in HeLa cells. Arch. ges. Virusforsch.28, 122–132 (1969).
Levine, S., Peebles, M., Hamilton, R.: Effect of respiratory syncytial virus infection on HeLa cell macromolecular synthesis. J. gen. Virol.37, 53–63 (1977).
Liew, F. Y., Russell, S. M.: Inhibition of pathogenic effect of effector T cells by specific suppressor T cells during influenza virus infection in mice. Nature304, 541–543 (1983).
Lin, Y.-L., Askonas, B. A.: Biological properties of an influenza A virus-specific killer T cell clone. J. Exp. Med.154, 225–234 (1981).
Luini, W., Boraschi, D., Alberti, S., Aleotti, A., Tagliabue, A.: Morphological characterization of a cell population responsible for natural killer activity. Immunol.43, 663–668 (1981).
MacDonald, N. E., Hall, C. B., Suffin, S. C., Alexson, C., Harris, P. J., Manning, J. A.: Respiratory syncytial viral infection in infants with congenital heart disease. New Eng. J. Med.307, 397–400 (1982).
McIntosh, K.: Interferon in nasal secretions from infants with viral respiratory tract infections. J. Pediat.93, 33–36 (1978).
McIntosh, K., Ellis, E. F., Hoffman, L. S., Lybass, T. G., Eller, J. J., Fulginiti, V. A.: The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. J. Pediat.82, 578–590 (1973).
McIntosh, K., Fishaut, J. M.: Immunopathologic mechanisms in lower respiratory tract disease of infants due to respiratory syncytial virus. Prog. Med. Virol.26, 94–118 (1980).
McIntosh, K., Masters, H. B., Orr, I., Chao, R. K., Barkin, R. M.: The immunologic response to infection with respiratory syncytial virus in infants. J. Inf. Dis.138, 24–32 (1978).
McIntosh, K., McQuillin, J., Gardner, P. S.: Cell-free and cell-bound antibody in nasal secretions from infants with respiratory syncytial virus infection. Infect. Immun.23, 276–281 (1979).
McMichael, A. J., Gotch, F. M., Dongworth, D. W., Clark, A., Potter, C. W.: Declining T-cell immunity, 1977–1982. Lancet2, 762–764 (1983).
McMichael, A. J., Gotch, F. M., Noble, G. R., Beare, A. S.: Cytotoxic T-cell immunity to influenza. New Eng. J. Med.309, 13–17 (1983).
McNulty, M. S., Bryson, D. G., Allan, G. M.: Experimental respiratory syncytial virus pneumonia in young calves: Microbiologic and immunofluorescent findings. Am. J. Vet. Res.44, 1656–1659 (1983).
Mathur, U., Bentley, D. W., Hall, C. B.: Concurrent respiratory syncytial virus and influenza A infections in the institutionalised elderly and chronically ill. Am. Intern. Med.93, 49–52 (1980).
Matthews, R. E. F.: Classification and nomenclature of viruses. Intervirology17, 104–105 (1982).
Meguro, H., Kervina, M., Wright, P. F.: Antibody-dependent cell-mediated cytotoxicity against cells infected with respiratory syncytial virus: characterisation ofin vitro andin vivo properties. J. Immunol.122, 2521–2526 (1979).
Merz, D. C., Scheid, A., Choppin, P. W.: Importance of antibodies to the fusion glycoprotein of paramyxoviruses in the prevention of spread of infection. J. Exp. Med.151, 275–288 (1980).
Milder, J. E., McDearmon, S. C., Walzer, P. D.: Presumed respiratory syncytial virus pneumonia in an adolescent compromised host. South. Med. J.72, 1195–1198 (1979).
Mills, B. G., Singer, F. R., Weiner, L. P., Holst, P. A.: Cell cultures from bone affected by Paget's disease. Arthritis Rheum.23, 1115–1120 (1980).
Mills, B. G., Singer, F. R., Weiner, L. P., Holst, P. A.: Immunohistological demonstration of respiratory syncytial virus antigens in Paget's disease of bone. Proc. Natl. Acad. Sci.78, 1209–1213 (1981).
Mills, B. G., Stabile, E., Holst, P. A., Graham, C.: Antigens of two different viruses in Paget's disease of bone. J. Dent. Res.61, 347 (1982).
Mills, J., van Kirk, J. E., Wright, P. F., Chanock, R. M.: Experimental respiratory syncytial virus infection of adults. J. Immunol.107, 123–130 (1971).
Mohanty, S. B., Lillie, M. G., Ingling, A. L.: Effect of serum and nasal neutralizing antibodies on bovine respiratory syncytial virus infection in calves. J. Inf. Dis.134, 409–413 (1976).
Mohanty, S. B., Rockemann, D. D., Davidson, J. P., Sharabrin, O. I.: Effect of vaccinal serum antibodies on bovine respiratory syncytial virus infection in calves. Am. J. Vet. Res.42, 881–883 (1981).
Mohanty, S. B., Rockemann, D. D., Davidson, J. P., Tripathy, R. N., Ingling, A. L.: Chemotherapeutic effect of 2-deoxy-D-glucose against respiratory syncytial virus infection in calves. Am. J. Vet. Res.42, 336–338 (1981).
Monto, A. S., Cavallaro, J. J.: The Tecumseh study of respiratory illnesses II. Patterns of occurrence of infection with respiratory pathogens, 1965–1969. Am. J. Epid.94, 280–289 (1971).
Monto, A. S., Lim, S. K.: The Tecumseh study of respiratory illness III. Incidence and periodicity of respiratory syncytial virus andMycoplasma pneumoniae infections. Am. J. Epid.94, 290–301 (1971).
Morales, F., Calder, M. A., Inglis, J. M., Murdoch, P. S., Williamson, J.: A study of respiratory infections in the elderly to assess the role of respiratory syncytial virus. J. Infect.7, 236–247 (1983).
Morris, J. A., Blount, R. E., Savage, R. E.: Recovery of cytopathic agent from chimpanzees with coryza. Proc. Soc. Exp. Biol. Med.92, 544–549 (1956).
Mufson, M. A., Levine, H. D., Wasil, R. E., Mocega-Gonzalez, H. E., Kranse, H. E.: Epidemiology of respiratory syncytial virus infection among infants and children in Chicago. Amer. J. Epid.98, 88–95 (1973).
Neligan, G. A., Steiner, H., Gardner, P. S., McQuillin, J.: Respiratory syncytial virus infection of the newborn. Br. Med. J. iii, 146–147 (1970).
van Nieuwstadt, A. P. K. M. I., Verhoeff, J., van den Ingh, T. S. G. A. M., Hartman, E. G.: Epizootiology of Pi-3-, Bovine RS- and IBR-virus infections in dairy herds with traditional calf rearing. Proc. 12th World Congress on Diseases of Cattle1, 124–130 (1982).
Norrby, E. H., Marusyk, H., Orvell, C.: Morphogenesis of respiratory syncytial virus in a green monkey kidney cell line (Vero). J. Virol.6, 237–242 (1970).
Norrby, E., Enders-Ruckle, G., Ter-Meulen, V.: Differences on the appearance of antibodies to structural components of measles virus after immunization with inactivated and live virus. J. Inf. Dis.132, 262–269 (1975).
Ogilvie, M. M., Vathenen, A. S., Radford, M., Codd, J., Key, S.: Maternal antibody and respiratory syncytial virus infection in infancy. J. Med. Virol.7, 263–271 (1981).
Paccaud, M. F., Jacquier, A.: A respiratory syncytial virus of bovine origin. Arch. ges. Virusforsch.30, 327–342 (1970).
Parrott, R. H., Kim, H. W., Arrobio, J. O., Hodes, D. S., Murphy, B. R., Brandt, C. D., Camargo, E., Chanock, R. M.: Epidemiology of respiratory syncytial virus infection in Washington, D.C. II. Infection and disease with respect to age, immunologic status, race and sex. Amer. J. Epidem.98, 289–300 (1973).
Parrott, R. H., Vargosko, A. J., Kim, H. W., Cumming, C., Turner, H., Huebner, R. J., Chanock, R. M.: Respiratory syncytial virus II. Serologic studies over a 34-month period of children with bronchiolitis, pneumonia, and minor respiratory diseases. J. Am. Med. Assoc.176, 653–657 (1961).
Parry, J. E., Shirodaria, P. V., Pringle, C. R.: Pneumoviruses: the cell surface of lytically and persistently infected cells. J. Gen. Virol.44, 479–491 (1979).
Peacock, D., Clarke, S. K. R.: Respiratory syncytial virus in Britain. Lancet2, 466 (1961).
Peebles, M., Levine, S.: Respiratory syncytial virus polypeptides: their location in the virion. Virology95, 137–145 (1979).
Peebles, M., Levine, S.: Metabolic requirements for the maturation of respiratory syncytial virus. J. gen. Virol.50, 81–88 (1980).
Peiris, J. S. M., Porterfield, J. S.: Antibody-mediated enhancement of flavivirus replication in macrophage-like cell lines. Nature282, 509–511 (1979).
Porter, D. P., Muck, K. B., Prince, G. A.: The age dependence of RSV growth in ferret lung can be shown in organ and monolayer cultures. Clin. Immunol. Immunopath.15, 415–423 (1980).
Potash, L., Tytell, A. A., Sweet, B. H., Machlowitz, R. A., Stokes, J., Weibel, R. E., Woodhour, A. F., Hilleman, M. R.: Respiratory virus vaccines: 1. Respiratory syncytial and parainfluenza virus vaccines. Amer. Rev. Res. Dis.93, 536–548 (1966).
Prince, G. A., Horswood, R. L., Berndt, J., Suffin, S. C., Chanock, R. M.: Respiratory syncytial virus infection in inbred mice. Infect. Immun.26, 764–766 (1979).
Prince, G. A., Horswood, R. L., Camargo, E., Koenig, D., Chanock, R. M.: Mechanisms of immunity to respiratory syncytial virus in cotton rats. Infect. Immun.42, 81–87 (1983).
Prince, G. A., Horswood, R. L., Camargo, E., Suffin, S. C., Chanock, R. M.: Parenteral immunization with live respiratory syncytial virus is blocked in seropositive cotton rats. Infect. Immun.37, 1074–1078 (1982).
Prince, G. A., Jenson, A. B., Horswood, R. L., Camargo, E., Chanock, R. M.: The pathogenesis of respiratory syncytial virus infection in cotton rats. Am. J. Pathol.93, 771–784 (1978).
Prince, G. A., Porter, D. D.: The pathogenesis of respiratory syncytial virus infection in infant ferrets. Am. J. Pathol.82, 339–350 (1976).
Prince, G. A., Potash, L., Horswood, R. L., Camargo, E., Suffin, S. C., Johnson, R. A., Chanock, R. M.: Intramuscular inoculation of live respiratory syncytial virus induces immunity in cotton rats. Infect. Immun.23, 723–728 (1979).
Pringle, C. R., Cross, A.: Neutralization of respiratory syncytial virus by cat serum. Nature276, 501–502 (1978).
Pringle, C. R., Parry, J. E.: Location and quantitation of antigen on the surface of virus-infected cells by specific bacterial adherence and scanning electron microscopy. J. Virol. Meth.1, 61–75 (1980).
Pringle, C. R., Shirodaria, P. V., Cash, P., Chiswell, D. J., Malloy, P.: Initiation and maintenance of persistent infection by respiratory syncytial virus. J. Virol.28, 199–211 (1978).
Pringle, C. R., Shirodaria, P. V., Gimenez, H. B., Levine, S.: Antigen and polypeptide synthesis by temperature-sensitive mutants of respiratory syncytial virus. J. gen. Virol.54, 173–183 (1981).
Public Health Laboratory Service: Respiratory syncytial virus infection in the elderly 1976–1982. Br. Med. J.287, 1618–1619 (1983).
Pullan, C. R., Hey, E. N.: Wheezing, asthma and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. Br. Med. J.284, 1665–1669 (1982).
Pullan, C. R., Toms, G. L., Martin, A. J., Gardner, P. S., Webb, J. K. G., Appleton, D. R.: Breast-feeding and respiratory syncytial virus infection. Br. Med. J.281, 1034–1036 (1980).
Raven, C., Maverakis, N. H., Eveland, W. C., Ackermann, W. W.: The sudden infant death syndrome: A possible hypersensitivity reaction determined by distribution of IgG in lungs. J. Foren. Sci.23, 116–128 (1978).
Rebel, A., Baslé, M., Pouplard, A., Malkani, K., Filmon, R., Lepatezour, A.: Bone tissue in Paget's disease of bone. Arthritis Rheum.23, 1104–1114 (1980).
Reichsteiner, J.: Thermal inactivation of respiratory syncytial virus in water and hypertonic solutions. J. gen. Virol.5, 397–403 (1969).
Report to the Medical Research Council: Respiratory syncytial virus infection: admissions to hospital in industrial, urban and rural areas. Br. Med. J.2, 796–798 (1978).
Richardson, L. S., Belshe, R. B., London, W. T., Sly, D. L., Prevar, D. A., Camargo, E., Chanock, R. M.: Evaluation of five temperature-sensitive mutants of respiratory syncytial virus in primates: 1. Viral shedding, immunologic response, and associated illness. J. Med. Virol.3, 91–100 (1978).
Richardson, L. S., Belshe, R. B., Sly, D. L., London, W. T., Prevar, D. A., Camargo, E., Chanock, R. M.: Experimental respiratory syncytial virus pneumonia in cebus monkeys. J. Med. Virol.2, 45–59 (1978).
Richardson, L. S., Yolken, R. H., Belshe, R. B., Camargo, E., Kim, H. W., Chanock, R. M.: Enzyme-linked immunosorbent assay for measurement of serological response to respiratory syncytial virus infection. Infect. Immun.20, 660–664 (1978).
Richardson-Wyatt, L. S., Belshe, R. B., London, W. T., Sly, D. L., Camargo, E., Chanock, R. M.: Respiratory syncytial virus antibodies in non-human primates and domestic animals. Lab. Anim. Sci.31, 413–415 (1981).
Richman, A. V., Tauraso, N. M.: Growth of respiratory syncytial virus in suspension cell culture. Appl. Microbiol.22, 1123–1125 (1971).
Rooney, J. C., Williams, H. E.: The relationship between proved viral bronchiolitis and subsequent wheezing. J. Pediat.79, 744–747 (1971).
Ross, C. A., Pinkerton, I. W., Asaad, F. A.: Pathogenesis of respiratory syncytial virus disease in infancy. Arch. Dis. Child.46, 702–704 (1971).
Rossi, C. R., Kiesel, G. K.: Serological evidence for the association of bovine respiratory syncytial virus with respiratory tract disease in Alabama cattle. Infect. Immun.10, 293–298 (1974).
Satake, M., Venkatesan, S.: Nucleotide sequence of the gene encoding respiratory syncytial virus matrix protein. J. Virol.50, 92–99 (1984).
Scarpelli, E. M.: Pulmonary physiology of the fetus and newborn child. Philadelphia: Lea and Febiger 1975.
Schauf, V., Purcell, C., Mizen, M., Mizen, S.: Lymphocyte transformation in response to antigens of respiratory syncytial virus. Proc. Soc. Exp. Biol. Med.161, 564–569 (1979).
Scott, R., Gardner, P. S.: Respiratory syncytial virus neutralizing activity in nasopharyngeal secretions. J. Hyg. Camb.68, 581–588 (1970).
Scott, R., Gardner, P. S.: The local antibody response to RS virus infection in the respiratory tract. J. Hyg. Camb.72, 110–120 (1974).
Scott, R., Kaul, A., Scott, M., Chiba, Y., Ogra, P. L.: Development ofin vitro correlates of cell-mediated immunity to respiratory syncytial virus infections in humans. J. Inf. Dis.137, 810–817 (1978).
Scott, R., De Landazuri, M. O., Gardner, P. S., Owen, J. J. T.: Human antibody-dependent cell-mediated cytotoxicity against target cells infected with respiratory syncytial virus. Clin. Exp. Immunol.28, 19–26 (1977).
Scott, R., Pullan, C. R., Scott, M., McQuillin, J.: Cell-mediated immunity in respiratory syncytial virus disease. J. Med. Virol.13, 105–114 (1984).
Scott, R., Scott, M., Toms, G. L.: Cellular and antibody responses to respiratory syncytial (RS) virus in human colostrum, maternal blood, and cord blood. J. Med. Virol.8, 55–66 (1981).
Senterfit, L. B., Baldridge, P. B.: Separation and concentration of respiratory syncytial virus (RSV) antigens. J. Immunol. Meth.4, 349–357 (1974).
Sieber, O. F., Lucas, D. L., Lohman, C., Larter, W., Giles, H., John, T. J.: Evidence for transplacental transfer of cell-mediated immunity. New Devel. Paed. Res.2, 483–486 (1977).
Sieber, O. F., Wilska, M. L., Riggin, R.: Elevated nitroblue tetrazolium dye reduction test response in acute viral respiratory disease. Pediat.58, 122–124 (1976).
Sims, D. G., Downham, M. A. P. S., Gardner, P. S., Webb, J. K. G., Weightman, D.: Study of 8 year-old children with a history of respiratory syncytial virus bronchiolitis in infancy. Br. med. J.1, 11–14 (1978).
Sims, D. G., Downham, M. A. P. S., McQuillin, J., Gardner, P. S.: Respiratory syncytial virus infection in north-east England. Br. med. J.2, 1095–1098 (1976).
Sims, D. G., Downham, M. A. P. S., Webb, J. K. G., Gardner, P. S., Weightman, D.: Hospital cross-infection on children's wards with respiratory syncytial virus and the role of adult carriage. Acta Paediatr. Scand.64, 541–545 (1975).
Sims, D. G., Gardner, P. S., Weightman, D., Turner, M. W., Soothill, J. F.: Atopy does not predispose to RSV bronchiolitis or postbronchiolitic wheezing. Br. med. J.282, 2086–2088 (1981).
Singer, F. R., Mills, B. G.: Viruses and Paget's disease. Lancet1, 69 (1983).
Smith, M. H., Frey, M. L., Dierks, R. E.: Isolation and characterisation of a bovine syncytial virus. Vet. Rec.94, 599 (1974).
Smith, T. F., McIntosh, K., Fishaut, M., Henson, P. M.: Activation of complement by cells infected with respiratory syncytial virus. Infect. Immun.33, 43–48 (1981).
Solomon, L. R., Raftery, A. T., Mallick, N. P., Johnson, R. W. G., Longson, M.: Respiratory syncytial virus infection following renal transplantation. J. Infect.3, 280–282 (1981).
Spelman, D. W., Stanley, P. A.: Respiratory syncytial virus pneumonitis in adults. Med. J. Aust.1, 430–431 (1983).
Stott, E. J., Bew, M. H., Taylor, G., Jebbett, J., Collins, A. P.: The characterisation and uses of monoclonal antibodies to respiratory syncytial virus. Develop. Biol. Standard. (in press, 1984).
Stott, E. J., Thomas, L. H., Collins, A. P., Crouch, S., Jebbett, J., Smith, G. S., Luther, P. D., Caswell, R.: A survey of virus infections of the respiratory tract of cattle and their association with disease. J. Hyg.85, 257–270 (1980).
Stott, E. J., Thomas, L. H., Taylor, G., Collins, A. P., Jebbett, J., Crouch, S.: A comparison of three vaccines against respiratory syncytial virus in calves. J. Hyg.93, 251–261 (1984).
Suffin, S. C., Prince, G. A., Hocko, J., Chanock, R. M.: Immunoenzymatic examination of autoptic tissues from the outbreak of fatal infantile disease in Naples, in 1978–1979. Ann. Ist. Super. Sanita17, 777–782 (1981).
Suffin, S. C., Prince, G. A., Muck, K. B., Porter, D. D.: Immunoprophylaxis of respiratory syncytial virus infection in the infant ferret. J. Immunol.123, 10–14 (1979).
Sun, C.-S., Wyde, P. R., Knight, V.: Correlation of cytotoxic activity in lungs to recovery of normal and gamma-irradiated cotton rats from respiratory syncytial virus infection. Amer. Rev. Resp. Dis.128, 668–672 (1983).
Sun, C.-S., Wyde, P. R., Wilson, S. Z., Knight, V.: Cell-mediated cytotoxic responses in lungs of cotton rats infected with respiratory syncytial virus. Amer. Rev. Resp. Dis.127, 460–464 (1983).
Suto, T., Yano, N., Ikeda, M., Miyamoto, M., Takai, S., Shigeta, S., Himema, Y., Ishida, N.: Respiratory syncytial virus infection and its serologic epidemiology. Am. J. Epidem.82, 211–224 (1965).
Taylor, B., Wadsworth, J., Golding, J., Butler, N.: Breast-feeding, bronchitis, and admissions for lower-respiratory illness and gastroenteritis during the first five years. Lancet1, 1227–1229 (1982).
Taylor, G., Stott, E. J., Bew, M., Fernie, B. F., Cote, P. J.: Monoclonal antibodies protect against respiratory syncytial virus. Lancet2, 976 (1983).
Taylor, G., Stott, E. J., Bew, M., Fernie, B. F., Cote, P. J., Collins, A. P., Hughes, M., Jebbett, J.: Monoclonal antibodies protect against respiratory syncytial virus infection in mice. Immunol.52, 137–142 (1984).
Taylor, G., Stott, E. J., Hughes, M., Collins, A. P.: Respiratory syncytial virus infection in mice. Infect. Immun.43, 649–655 (1984).
Thomas, L. H., Stott, E. J., Collins, A. P., Crouch, S., Jebbett, J.: Infection of gnotobiotic calves with a bovine and human isolate of respiratory syncytial virus. Modification of the response by dexamethasone. Arch. Virol.79, 67–77 (1984).
Thomas, L. H., Stott, E. J., Collins, A. P., Jebbett, J.: Experimental pneumonia in gnotobiotic calves produced by respiratory syncytial virus. Br. J. Exp. Path.65, 19–28 (1984).
Toms, G. L., Gardner, P. S., Pullan, C. R., Scott, M., Taylor, C.: Secretion of respiratory syncytial virus inhibitors and antibody in human milk throughout lactation. J. Med. Virol.5, 351–360 (1980).
Trepanier, P., Payment, P., Trudel, M.: Concentration of human respiratory syncytial virus using ammonium sulphate polyethylene glycol or hollow fibre ultrafiltration. J. Virol. Meth.3, 201–211 (1981).
Trepanier, P., Payment, P., Trudel, M.: Modified immunoprecipitation procedure for the identification of human respiratory syncytial virus polypeptides. J. Virol. Meth.7, 149–154 (1983).
Treuhaft, M. W.: A colorimetric assay for quantification of defective interfering particles of respiratory syncytial virus. J. gen. Virol.64, 1301–1309 (1983).
Treuhaft, M. W., Beem, M. O.: Defective interfering particles of respiratory syncytial virus. Infect. Immun.37, 439–444 (1982).
Twiggs, J. T., Larson, L. A., O'Connell, E. J., Ilstrup, D. M.: Respiratory syncytial virus infection ten-year follow-up. Clin. Pediat.20, 187–190 (1981).
Tyeryar, F. J.: Report of a Workshop on respiratory syncytial virus and parainfluenza viruses. J. Inf. Dis.148, 588–598 (1983).
Ueba, O.: Respiratory syncytial virus: II. Isolation and morphology of the glycoproteins. Acta Med. Okayama34, 245–254 (1980).
Ueba, O.: Purification and polypeptides of respiratory syncytial virus. Microbiol. Immunol.24, 361–364 (1980).
Uren, E. C., Williams, A. L., Jack, I., Rees, J. W.: Association of respiratory virus infections with sudden infant death syndrome. Med. J. Aust.1, 417–419 (1980).
Verhoeff, J., van Nieuwstadt, A. P. K. M. I.: A field trial with a bovine respiratory syncytial virus vaccine. Proceedings of XII World Congress on Diseases of Cattle, 182–188 (1982).
Walsh, E. E., Hruska, J.: Monoclonal antibodies to respiratory syncytial virus proteins: Identification of the fusion protein. J. Virol.47, 171–177 (1983).
Walsh, E. E., Schlesinger, J. J., Brandriss, M. W.: Purification and characterisation of GP90, one of the envelope glycoproteins of respiratory syncytial virus. J. gen. Virol.65, 761–767 (1984).
Walsh, E. E., Schlesinger, J. J., Brandriss, M. W.: Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies. Infect. Immun.43, 756–758 (1984).
Ward, K. A., Lambden, P. R., Ogilvie, M. M., Watt, P. J.: Antibodies to respiratory syncytial virus polypeptides and their significance in human infection. J. gen. Virol.64, 1867–1876 (1983).
Weibel, R. E., Stokes, J., Leagus, M. B., Mascoli, C. C., Hilleman, M. R.: Respiratory virus vaccines. V. Field evaluation for efficacy of Heptavalent vaccine. Amer. Rev. Resp. Dis.94, 362–379 (1966).
Wellemans, G., van Opdenbosch, E., Boucque, C. V., Leunen, J., Strobbe, R.: Vaccination des bovins contre le virus respiratoire syncytial (RSB) au moyen d'une souche atténuée. Ann. Méd. Vét.122, 527–536 (1978).
Welliver, R. C., Kaul, A., Ogra, P. L.: Cell-mediated immune response to respiratory syncytial virus infection: Relationship to the development of reactive airway disease. J. Pediat.94, 370–375 (1979).
Welliver, R. C., Kaul, T. N., Ogra, P. L.: The appearance of cell-bound IgE in respiratory-tract epithelium after respiratory syncytial virus infection. New Eng. J. Med.303, 1198–1202 (1980).
Welliver, R. C., Kaul, T. N., Putnam, T. I., Sun, M., Riddlesberger, K., Ogra, P. L.: The antibody response to primary and secondary infection with respiratory syncytial virus: Kinetics of class-specific responses. J. Ped.96, 808–813 (1980).
Welliver, R. C., Wong, D. T., Sun, M., Middleton, E., Vaughan, R. S., Ogra, P. L.: The development of respiratory syncytial virus-specific IgE and the release of histamine in nasopharynageal secretions after infection. New Eng. J. Med.305, 841–846 (1981).
Wright, P. F., Belshe, R. B., Kim, H. W., van Voris, L. P., Chanock, R. M.: Administration of a highly attenuated live respiratory syncytial virus vaccine to adults and children. Infect. Immun.37, 397–400 (1982).
Wright, P. F., Mills, J., Chanock, R. M.: Evaluation of a temperature-sensitive mutant of respiratory syncytial virus in adults. J. Inf. Dis.124, 505–511 (1971).
Wright, P. F., Woodend, W. G., Chanock, R. M.: Temperature-sensitive mutants of respiratory syncytial virus:In vivo studies in hamsters. J. Inf. Dis.122, 501–512 (1970).
Wulff, H., Kidd, P., Wenner, H. A.: Respiratory syncytial virus: Observations on antigenic heterogeneity. Proc. Soc. exp. Biol. Med.115, 240–243 (1964).
Wunner, W. H., Faulkner, C. P., Pringle, C. R.: Respiratory syncytial virus: some biological and biochemical properties. In:Mahy, B., Barry, R. (eds.), Negative Strand Viruses, 193–201. New York: Academic Press 1975.
Wunner, W. H., Pringle, C. R.: Respiratory syncytial virus proteins. Virology73, 228–243 (1976).
Wyde, P. R., Cate, T. R.: Cellular changes in the lungs of mice infected with influenza virus. Characterization of the cytotoxic responses. Infect. Immun.22, 423–429 (1978).
Wyde, P. R., Sun, C.-S., Knight, V.: Replication of respiratory syncytial virus in lungs of immunodeficient mice. J. Retic. Soc.34, 125–129 (1983).
Zakstilskaya, L. Ya., Almeida, J. D., Bradstreet, C. M. P.: The morphological characterization of respiratory syncytial virus by a simple electron microscope technique. Acta Virol.11, 420–423 (1967).
Zygraich, N.: Vaccination against RS virus: a five year experience with Rispoval. Proceedings of XII World Congress on Diseases of Cattle, 189–195 (1982).
Zygraich, N., Wellemans, G.: Immunological markers of an attenuated bovine respiratory syncytial virus vaccine. Zbl. Vet. Med. B.28, 355–362 (1981).
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Stott, E.J., Taylor, G. Respiratory syncytial virus. Archives of Virology 84, 1–52 (1985). https://doi.org/10.1007/BF01310552
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DOI: https://doi.org/10.1007/BF01310552