Summary
Monoclonal antibodies detect evident antigenic variations in NDV HN and F protein. However, the A/PMV-1 viruses can be identified by HI test using a preparation made of the combination of two different monoclonals.
A primary evaluation of the pathogenicity of the isolated viruses can be made by HI test using monoclonal antibodies but needs always confirmation using conventional pathogenicity tests.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Alexander DJ (1982) Avian paramyxoviruses-other than Newcastle disease virus. World's Poult Sci J 38: 97–105
Alexander DJ, Russell PH, Collins MS (1984) Paramyxovirus type 1 infections of racing pigeons: 1 characterization of isolated viruses. Vet Rec 114: 444–446
Allan WH, Gough RE (1974) A standard hemagglutination inhibition test for Newcastle diseases. 1. A comparison of macro and micro methods. Vet Rec 95: 120–123
Allan WH, Lancaster JE, Toth B (1978) Newcastle disease vaccines. Food and Agriculture Organization of the United Nations, Rome
Arias-Ibarrondo J, Mikami T, Yamamoto H, Furuta Y, Ishioka S (1978) Studies on a paramyxovirus isolated from Japanes sparrow-hawks(Accipter virgatus gularis). Jpn J Vet Sci 40: 315–323
Bankowski RA, Kinjo J (1965) Tissue culture systems with Newcastle disease virus and relationship of antigenicity to immunogenicity among strains. Avian Dis 9: 157–170
Gomez-Lillo M, Bankowski RA, Wiggins AD (1974) Antigenic relationships among viscerotropic-velogenic and domestic strains of Newcastle disease virus. Am J Vet Res 35: 471–475
Hannoun C (1977) Isolation from birds of influenza viruses with human neuraminidase. Biol Standard 39: 461–468
Ishida M, Nerome K, Matsumoto M, Mikami T, Oya A (1985) Characterization of Reference strains of Newcastle Disease virus (NDV) and NDV-like isolates by monoclonal antibodies to HN subunits. Arch Virol 85: 109–121
Le Long, Portetelle D, Ghysdael J, Gonze M, Burny A, Meulemans G (1986) Monoclonal antibodies to hemagglutinin and fusion glycoproteins of Newcastle disease virus: relationship between glycosylation and reactivity. J Virol 57: 1198–1202
Meulemans G, Gonze M, Carlier MC, Petit P, Burny A, Le Long (1986) Anti-genic and biological characterization of avian paramyxovirus type 1 isolates from pigeons. Arch Virol 87: 151–161
Nishikawa K, Isomura S, Suzuki S, Watanabe E, Hamaguchi M, Yoshida T, Nagai Y (1983) Monoclonal antibodies to the HN glycoprotein of Newcastle disease virus. Biological characterization and use for strain comparisons. Virology 130: 318–330
Pennington TH (1978) Antigenic differences between strains of Newcastle disease virus. Arch Virol 56: 345–351
Reed LJ, Muench H (1938) A simple method of estimating fifty percent end points. Am J Hyg 27: 493–497
Russell PH, Alexander DJ (1983) Antigenic variation of Newcastle disease virus strains detected by monoclonal antibodies. Arch Virol 75: 243–253
Schloer G (1974) Antigenic relationships among Newcastle disease virus mutants obtained from laboratory strains and from recent California isolates. Infect Immun 10: 724–732
Schloer G, Spalatin J, Hanson RP (1975) Newcastle disease virus antigens and strain variations. Am J Vet Res 36: 505–508
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Meulemans, G., Gonze, M., Carlier, M.C. et al. Evaluation of the use of monoclonal antibodies to hemagglutinin and fusion glycoproteins of Newcastle disease virus for virus identification and strain differentiation purposes. Archives of Virology 92, 55–62 (1987). https://doi.org/10.1007/BF01310062
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01310062