Summary
Melatonin concentrations in serum and urine were examined following oral administration of melatonin to dogs. Four different doses of melatonin ranging from 10 to 80 mg per kg of body weight were given. Melatonin was rapidly absorbed and reached a maximum serum level after 20–30 min, with a distribution phase of 3.5 hours and elimination half life (t1/2) of 5 hours. The fraction excreted in the urine was 0.25% of the administrated dose during the first 5 hours. These results as well as the diurnal rhythm of serum melatonin in the dog are similar to corresponding data reported in the human.
Article PDF
Avoid common mistakes on your manuscript.
References
Arendt, J., Wetterberg, L., Heyden, T., Sizonenko, P. C., Paunier, L. Radioimmunoassay of melatonin: Human serum and cerebrospinal fluid. Hormone Res.8, 65–75 (1977).
Kennaway, D. J., Frith, R. G., Phillipou, G., Matthews, C. D., Seamark, R. F. A specific radioimmunoassay for melatonin in biological tissue and fluids and its validation by gas chromatography-mass spectrometry. Endocrinology101, 119–127 (1977).
Wetterberg, L., Eriksson, O., Friberg, Y., Vangbo, B. A simplified radioimmunoassay for melatonin and its application to biological fluids. Preliminary observations on the half life of plasma melatonin in man. Clin. Chem. Acta86, 169–177 (1978).
Wetterberg, L. Clinical importance of melatonin. In: Progress in Brain Research, Vol. 52 (Ariëns Kappers, J., Pévet, P., eds.), pp. 539–547. Amsterdam: Elsevier. 1979.
Author information
Authors and Affiliations
Additional information
This study was presented September 30, 1980 by L. Wetterberg at the International Symposium on Melatonin in Bremen, Federal Republic of Germany.
Rights and permissions
About this article
Cite this article
Sääf, J., Wetterberg, L., Bäckström, M. et al. Melatonin administration to dogs. J. Neural Transmission 49, 281–285 (1980). https://doi.org/10.1007/BF01252131
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01252131