Abstract
A new simple and sensitive spectrophotometric procedure for the determination of sulfacetamide sodium (I), sulfadiazine (II), sulfadimidine (III) and sulfathiazole (IV) is based on the reaction of the drug with acetylacetone-formaldehyde reagent to give a yellow product having λmax at 400 nm. Optimization of the reaction conditions has been investigated. A linear correlation was obtained between absorbance at λmax and the concentration. The Beer's law limits of I, II, III and IV are 4–80, 4–72, 4–60 and 4–80 μg/ml, respectively. For more accurate results, Ringbom optimum concentration ranges were evaluated to be 6–76, 8–66, 6–56 and 8–75 μg/ml for I, II, III and IV, respectively. The molar absorptivities and Sandell sensitivities for all sulfa drugs under consideration were evaluated. Relative standard deviations of 0.98, 1.07, 0.86 and 0.79% were obtained for I, II, III and IV, respectively. The method has been compared to the official method and found to be simple, accurate (t-test) and reproducible (F-test). The developed procedures were applied for bulk sulfa drugs and some of their dosage forms without interferences from additive and common prescribed drugs.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
R. F. Doerge (ed.),Wilson and Gisvold's Text book of Organic Medicinal and Pharmaceutical Chemistry, 8th Ed., Lippincott, Philadelphia, 1982, pp. 190, 191.
A. C. Bratton, F. K. Marshall,J. Biol. Chem. 1939,128, 537.
Z. Zhang, B. Xiang, Zhang, D. An,Fenxi Hauxue 1992,20, 652.
I. M. Barwick, P. Warwick, N. T. Crosby,Analyst 1993,118, 489.
M. E. Ei-Kommos, K. M. Emara,Analyst 1988,113, 133.
S. S. Artemchenko, V. M. Sadivskii, V. V. Petrenko,Farm. Zh. 1990,5, 74.
M. M. El-Laithy, S. Z. El-Khateeb, M. F. El-Tarras,Microchem. J. 1986,33, 168.
A. S. Amin, G. O. El-Sayed, Y. M. Issa,Microchem. J. 1995,51, in press.
M. C. Mahedero, J. J. Aaron,Analusis 1992,20, 53.
M. Sanchez-Pena, F. Salinas, M. C. Mahedero, J. J. Aaron,Talanta 1994,41, 233.
M. C. Mahedero, J. J. Aaron,Anal. Chim. Acta 1992,269, 193.
A. Al-Weheid, A. Townshend,Anal. Chim. Acta 1986,186, 289.
R. Montes, J. J. Laserna,Analyst 1990,115, 160.
S. S. Hassan, M. H. El-Desouki,J. Assoc. Off. Anal. Chem. 1981,64, 1158.
K. Nikolies,Acta Pharmacol. Hung. 1976,46, 205.
Y. Zhan, G. Lu, R. Zhan,Huaxue Shijie 1991,32, 549.
E. J. Greenhow, L. E. Spencer,Anal. Chem. 1975,47, 1384.
M. Blesova,Farm. Obz.,1982,51, 365;Int. Pharmacol. Abstr. 1983,20, 829.
A. Srivastava, R. Abbi, A. Gupta, B. Susmeet,Mikrochim. Acta 1989,III, 81.
G. Cantelli Forti, M. E. Fracosso,Rev. Farmacol. Ter. 1971,2, 301.
M. Shibata, K. Shigemori, Y. Imamura,Chemotherapy (Tokyo) 1974,22, 1424.
L. V. Walker, J. R. Walsh, J. J. Webber,J. Chromatogr. 1992,595, 179.
J. D. Brewster, A. R. Lightfield, R. A. Barford,J. Chromatogr. 1992,598, 23.
R. B. Taylor, R. M. E. Richards, J. Z. Xing,Analyst 1992,117, 1425.
United States Pharmacopeia, 21st Rev., National Rockville, MD., 1985, pp. 988–972 and 977.
British Pharmacopoeia, H. M. Stationery Office, London, 1993, pp. 640, 641, 646.
A. Csiba,Proc. Hung, Annu. Meet. Biochem. 1979,19, 291;Chem. Abstr. 1980,92, 64836j.
M. B. Devani, I. T. Patel, T. M. Patel,Anal. Lett. 1991,24, 971.
M. B. Devani, I. T. Patel, T. M. Patel,Talanta 1992,39, 1391.
J. C. Miller, J. N. Miller,Statistics for Analytical Chemistry, 2nd Ed., Ellis Horwood, Chichester, 1988.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Amin, A.S., Zareh, M.M. Acetylacetone-formaldehyde reagent for the spectrophotometric determination of some sulfa drugs in pure and dosage forms. Mikrochim Acta 124, 227–233 (1996). https://doi.org/10.1007/BF01242820
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01242820