Summary
Sodium β-hydroxybutyrate was infused for 1.5 h in 8 normal subjects, at a constant rate of 5 mmoles/ kg/h. Equimolar amounts of sodium chloride were infused in 5 control subjects. — The induced hyperketonaemia provoked the following changes in peripheral blood: a fall in glycaemia (15 mg/100 ml) and in plasma NEFA concentration (50%) without concomitant modifications of insulin concentrations. These results indicate that the glucose and NEFA changes observed are not mediated by a pancreatic stimulation.
Résumé
Les auteurs ont étudié chez 8 sujets normaux les effets d'une perfusion de β-hydroxy-butyrate de sodium (5 m mol/kg/h pendant 1.6 h) sur la concentration sanguine en glucose, en acides gras libres, en corps cétoniques et en insuline dans le sang veineux périphérique. Cinq sujets témoins ont été perfuses à l'aide de solution équimolaires de NaCl. — L'hypercétonémie provoque une chute de la glycémie d'environ 15 mg/100 ml, une chute des NEFA atteignant 50%, sans modifications concommitantes de l'insulinémie. Ces résultats plaident contre l'intervention d'une stimulation pancréatique dans la chute de la glycémie et des NEFA.
Zusammenfassung
Natrium-μ-hydroxy-butyrat wurde 8 Normalpersonen während 1.5 Std bei konstanter Geschwindigkeit von 5 mMol/kg/Std infundiert. 5 Kontrollpersonen erhielten äquimolekulare Mengen einer Kochsalzlösung. — Die so bewirkte Erhöhung der Ketokörper-Spiegel führte im peripheren Blut zu folgenden Veränderungen: Absinken des Blutzuckers um 15 mg %, Abfall der Plasma-FFS auf die Hälfte ohne gleichzeitige Änderung der Insulinspiegel. Diese Ergebnisse sprechen dafür, daß die Änderung der Glucose- und FFS-Konzentrationen nicht durch eine Stimulierung des Pankreas ausgelöst wird.
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Balasse, E., Ooms, H.A. Changes in the concentrations of glucose, free fatty acids, insulin and ketone bodies in the blood during sodium \-hydroxybutyrate infusions in man. Diabetologia 4, 133–135 (1968). https://doi.org/10.1007/BF01219433
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DOI: https://doi.org/10.1007/BF01219433