Abstract
The fine needle aspiration biopsy was performed in 91 patients including 57 cases of retrobulbar tumors done under CT control. All aspirates were cytologically examined. In 21 cases immunocytochemical examination was performed in order to distinguish poorly differentiated neoplasms. In 19 cases malignant lymphoma was distinguished from pseudolymphoma. Cytological diagnosis was confirmed by histopathological examination in 77 cases /84%/. One result was false positive, 3-false negative. The value of immunocytochemical methods in differential diagnosis of poorly differentiated neoplasms was stressed.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Bibbo M. Comprehensive cytology in: B. Saunders Company. Philadelphia 1990.
Cavanagh HD, Green WR, Goldberg HK. Multicentric sebaceous adenocarcinoma of the Meibomian gland. Amer J Ophthalmol 1974, 326–332.
Chosia M. Use of immunocytochemical techniques in differential diagnosis of neoplasms in fine needle aspirates. Pomorska Akademia Medyczna. Szczecin Poland 1991.
Cintorino M et al. Expression of actin isoforms and intermediate filament proteins in childhood orbital rhabdomyosarcoma. J Submicrosc Cytol Pathol 1989, 21: 409–419.
Domagala W et al. Differential diagnosis of lymph node aspirates by intermediate filament typing of tumor cells. Acta Cytol 1986, 30: 225–234.
Domagała W et al. Decisive role of intermediate typing oftumor cells in the differential diagnosis of difficult fine needle aspirates. Acta Cytol 1987, 31: 253–266.
Domagala W et al. Immunocytochemical criteria in the differential diagnosis of malignant melanoma versus carcinoma, lymphoma and sarcoma in fine needle aspirates. Pat. Pol. 1991, 42: 73–78.
Dresner Sc, Kennerdell J S, Dekker A. Fine needle aspiration biopsy of metastatic orbital tumors. Surv Ophthalmol 1983, 27: 397–398.
Ellis J H et al. Lymphoid tumors of the ocular adnexa. Ophthalmol 1985, 92: 1311–1324.
Gamel J W, Eiferman R A, Guibor P. Mucoepidermoid carcinoma of the conjunctiva. Arch Ophthalmol Chicago 1984, 102: 73–731.
Gibbs R A. DNA amplification by the polymerase chain reaction. Anal Chem 1990, 62: 1202–1214.
Graham J, Joung S E, Luna M. An unusual case of metastatic carcinoma of the eyelid. Amer J Ophthalmol 1978, 86: 400–402.
Holbach L et al. Zur immunozytochemischen Diagnose embryonaler Rhabdomyosarcome der Orbita. Klin Mbl. Augenheil 1989, 195: 190–195.
Jakobiec F A, Chattock A. Aspiration cytodiagnosis of eyelid tumors. Arch Ophthalmol 1979, 97: 1907–34.
Kennerdell J S et al. Orbital fine needle aspiration biopsy. Amer J Ophthalmol 1985, 99: 547–551.
Koss L G, Woyke S, Olszewski O. Aspiration Biopsy. Cytologic Interpretation and Histologic Bases. Sec ed Iqaku - Shoin, New York, 1992.
Krzystolik Z. Clinical value of fine needle aspiration biopsy and computed tomography in diagnosing pathological changes of the orbit and ocular adnexa. Pomorska Akademia Medyczna. Szczecin - Poland 1989.
Lubiński J, Chosia M, Huebner K. Molecular genetic analysis in the diagnosis of lymphoma in fine needle aspiration biopsies. I. Lymphomas versus benign lymphoproliferative disorders. Anal Quant Cytol Histol 1988, 10: 391–398.
Mansour A M, Hidayat A A. Metastatic eyelid disease. Ophthalmology 1987, 94: 667–670.
Midena E et al. Fine needle aspiration biopsy in ophthalmology. Surv Ophthalmol 1985, 29: 410–422.
Morgan G, Harry J. Lymphatic tumors of interdeterminate nature: a 5 year follow up of 98 conjunctival an orbital lesion. Brit J Ophthalmol 1978, 62: 381–383.
Perlman E, Mc Mahon R L. Sebaceous gland carcinoma of the eyelid. Amer J Ophthal 1978, 86: 699–703.
Shields J A, Shields C L. Orbital Rhabdomyosarcoma. Arch Ophthalmol 1987, 105: 700–701.
Vogiatzis K V. Lymphoid tumors of the orbit and ocular adnexa: A long term follow -up. Ann Ophthalmol 1984, 1046–1055.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Krzystolik, Z., Rosławska, A. & Bedner, E. The cytological, immunocytochemical and molecular genetic analysis in diagnosis of the neoplasms of the eye, eye adnexa and orbit. Doc Ophthalmol 88, 155–163 (1994). https://doi.org/10.1007/BF01204613
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01204613