Abstract
One of the functions of the human lens is filter light between 300–400 nm from reaching the retina. The lens is therefore continually under photooxidative stress. In the young lens the primary absorbing species is the O-beta glucoside of 3-hydroxykynurenine (3-HKG) which has a maximum at 365 nm. Photophysical studies have demonstrated that absorptions by this compound in the short term are relatively benign to the lens, but in the long term can lead to the photochemical loss of 3-HKG with the concomitant yellowing of lens proteins. It will be proposed that part of this yellowing is due to the photochemically induced attachment of 3-HKG to lens proteins. The yellowing of lens proteins leads to a drastic increase in the number of photons absorbed by the lens. This, along with the age-related losses of antioxidants such as GSH will increase the photooxidative stress on the lens. Considering the foregoing and various epidemiological, model and biochemical studies, it can be concluded that light is most likely one of the causative factors in cataractogenesis.
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Roberts J, Dillon J. A comparison of the photodynamic effect of sensitizing drugs on lens protein. Lens Res 1985; 2: 183.
Dillon J, Atherton SJ. Time resolved spectroscopic studies on the intact human lens. Photochem Photobiol 1989; 51: 465–68.
Dillon J. Photophysics and photobiology of the eye. Invited review. J Photochem Photobiol B Biol 1991; 10: 23–40.
Dillon J, Wang RH, Atherton S. Photochemical and photophysical studies on human lens constituents. Photochem Photobiol 1990; 52: 849–54.
Ellozy A, Wang RH, Dillon J. Model studies on the photochemical production of lenticular fluorophores. Photochem Photobiol 1994; 59: 479–84.
Yu NT, Barron B, Kuck F. Distribution of two metabolically related fluorophores in human lens measured by laser microprobe. Exp Eye Res 1989; 49: 189–94.
Taylor HR, West SK, Rosenthal FSet al. Effect of ultraviolet radiation on cataract formation. N Engl J Med 1988; 319: 1429–1433.
Zigman S, Paxhia T, McDaniel T, Lou M, Yu NT. Effect of chronic near-ultraviolet radiation on the gray squirrel lensin vivo. Invest Ophthalmol Vis Sci 1991; 32: 1723–32.
Yappert M, Borchman D, Byrdwell W. Comparison of specific blue and green fluorescence in cataractous versus normal lens fractions. Invest Ophthalmol Vis Sci 1993; 34: 630–36.
Coroneo M, Muller-Stolzenburg N, Ho A. Peripheral light focusing by the anterior eye and the ophthalmohelioses. Ophthalmol Sur 1991; 22: 705–11.
Klein B, Klein R, Linton K, Magli Y, Neider M. Assessment of cataracts from photographs in the Beaver Dam eye study. Ophthalmology 1990; 97: 1428–33.
Schein OD, West S, Munoz B, Vitale S, Maguire M, Taylor HR, Bressler NM. Cortical lenticular opacification: distribution and location in a longitudinal study. Invest Ophthalmol Vis Sci 1994; 35: 363–366
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Dillon, J. UV-B as a pro-aging and pro-cataract factor. Doc Ophthalmol 88, 339–344 (1995). https://doi.org/10.1007/BF01203686
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DOI: https://doi.org/10.1007/BF01203686