Abstract
A wide variety of materials is being increasingly used in medical practice for the treatment of patients in which the materials come into direct and often sustained contact with the tissues of the body. The commonly-known examples of hip replacements, contact and intraocular lenses and pace-makers serve to emphasize the importance of this subject. Because the body is so well equipped to reject any intruding object, whether that is a bacterium or a splinter of wood, the materials which are to stand any chance of success within this hostile yet sensitive milieu must be chosen very carefully. The subject of biomaterials represents an almost unique blend of physical and biological sciences, and it is becoming increasingly important that these aspects are drawn together to help in the development of quality biomaterials that are able to perform optimally in this environment. The key to this subject lies in the interactions that take place between biomaterials and these tissues and this review is aimed at providing, for the materials scientist, an understanding of the mechanisms of these interactions.
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Williams, D.F. Tissue-biomaterial interactions. J Mater Sci 22, 3421–3445 (1987). https://doi.org/10.1007/BF01161439
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DOI: https://doi.org/10.1007/BF01161439