Abstract
Approximate formulae of sample sizes for Schuirmann's two one-sided tests procedure are derived for bioequivalence studies with the 2×2 crossover design. These formulae are simple enough to be carried out with a pocket calculator.
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References
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Liu, Jp., Chow, SC. Sample size determination for the two one-sided tests procedure in bioequivalence. Journal of Pharmacokinetics and Biopharmaceutics 20, 101–104 (1992). https://doi.org/10.1007/BF01143188
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DOI: https://doi.org/10.1007/BF01143188