Abstract
Chlorpromazine, mepacrine, tetracaine, dibucaine, chloroquine, and procaine have been shown to inhibit the iron- and ascorbate-induced lipid peroxidation of skeletal-muscle hornogenates in vitro. These compounds are known to be inhibitors of phospholipase activity, but they were also found to be effective in blocking free-radical-mediated damage to lipids in denatured homogenates, to linoleate suspensions, and to glutamic acid solutions where phospholipase activity was not a relevant factor. The inhibitory action did not appear to be related to any iron-binding activity of the compounds.
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Jackson, M.J., Jones, D.A. & Harris, E.J. Inhibition of lipid peroxidation in muscle homogenates by phospholipase A2 inhibitors. Biosci Rep 4, 581–587 (1984). https://doi.org/10.1007/BF01121915
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DOI: https://doi.org/10.1007/BF01121915