Abstract
Pancreastatin is a novel 49-amino acid peptide with a C-terminal glycine amide. The peptide was isolated from porcine pancreatic extracts and shows a structural similarity to chromogranin A. The effect of synthetic porcine pancreastatin on blood glucose levels and hepatic glycogen content was investigated in ratsin vivo. Pancreastatin (300 pmol/kg) produced a time-dependent decrease in glycogen content of liver and a slight hyperglycemia. Basal plasma insulin and glucagon levels were not modified by pancreastatin. We suggest that pancreastatin could play a biological role in the glucose metabolism through a glycogenolytic effect.
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Sanchez, V., Calvo, J.R. & Goberna, R. Glycogenolytic effect of pancreastatin in the rat. Biosci Rep 10, 87–91 (1990). https://doi.org/10.1007/BF01116856
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DOI: https://doi.org/10.1007/BF01116856