Abstract
Triacylglycerol/fatty acid substrate cycling was measuredin vivo in brown adipose tissue (BAT) and white adipose tissue (WAT) of fed, starved and refed rats. Starvation (24 h) significantly decreased the rate of cycling in BAT, and refeeding chow diet led to a rapid, 6-fold increase in cycling. Cycling rate in WAT was much lower than in BAT, and was not influenced by fasting or refeeding. Similar rates of cycling were found in epididymal, mesenteric, subcutaneous, and scapular WAT depots. Sympathetic denervation of interscapular BAT abolished the response of the tissue to refeeding, as did acute suppression of insulin secretion. Similarly, rats fasted for 3 days showed no acute increase in the activity of the cycle following refeeding.
References
Agius, L. and Williamson, D. H. (1980).Biochem. J. 190:477–480.
Andrews, P. L. R., Rothwell, N. J. and Stock, M. J. (1985).Am. J. Physiol. 249:E239-E243.
Brooks, B. J. (1981)D. Phil. Thesis, University of Oxford.
Brooks, B. J., Arch, J. R. S. and Newsholme, E. A. (1982).FEBS Lett. 146:327–330.
Brooks, B. J., Arch, J. R. S. and Newsholme, E. A. (1983).Biosci. Rep. 3:263–267.
Elia, M., Zed, C., Neale, G. and Livesey, G. (1987)Metabolism 36:251–255.
Ferré, P., Burnol, A. F., Leturque, A., Terretaz, J., Penicaud, L., Jeanrenaud, B. and Girard, J. (1985).Biochem. J. 233:249–252.
Foster, D. O., Depocas, F. and Zuker, M. (1982).Can. J. Physiol. Pharmacol. 60:747–754.
Glick, Z., Wu, S. Y., Lupien, J., Reggio, R., Bray, G. A. and Fisher, D. A. (1985).Am. J. Physiol. 249:E519-E524.
Hammond, V. A. and Johnston, D. G. (1987).Metabolism 36:308–313.
Hansson, P., Newsholme, E. A. and Williamson, D. H. (1987).Biochem. J. 243:267–271.
Howland, R. J. and Bond, K. B. (1987).Eur. J. Biochem. 169:155–166.
Isler, D., Hill, H. P. and Meier, M. K. (1987).Biochem. J. 245:789–793.
Landsberg, L. and Young, J. B. (1983). In:Mammalian Thermogenesis (Girardier, L. and Stock, M. J., ed.), Chapman and Hall, London and New York, pp. 99–140.
McCormack, J. G. and Denton, R. M. (1977).Biochem. J. 166:627–630.
Mercer, S. W. and Trayhurn, P. (1977).Biosci. Rep.,4:933–940.
Mercer, S. W. and Trayhurn, P. (1986).FEBS Lett 195:12–16.
Mills, I., Barge, R. M., Silva, J. E. and Larsen, P. R. (1987).Biochem. Biophys. Res. Commun. 143:81–86.
Newsholme, E. A. and Crabtree, B. (1976).Biochem. Soc. Symp. 41:61–110.
Nicholls, D. G. and Locke, R. M. (1984).Physiol. Rev 46:1–64.
Rothwell, N. J. and Stock, M. J. (1981).Metabolism 30:673–678.
Rothwell, N. J. and Stock, M. J. (1986). In:Brown Adipose Tissue (Trayhurn, P. and Nicholls, D. G., ed.), Edward Arnold, London, pp. 269–298.
Rothwell, N. J., Saville, M. E. and Stock, M. J. (1983).Am. J. Physiol. 245:E160-E165.
Rothwell, N. J., Stock, M. J. and Warwick, B. P. (1985).Metabolism 34:43–47.
Seydoux, J., Trimble, E. R., Bouillaud, F., Assimacopoulos-Jeannet, F., Bas, S., Ricquier, D., Giacobino, J. P. and Girardier, L. (1984).FEBS Lett.166:141–145.
Silva, J. E. and Larsen, P. R. (1986).Am. J. Physiol. 251:E639-E643.
Simon, E. and Kraicer, P. F. (1966).Israel J. Med. Sci. 2:785–799.
Smith, S. A., Young, P. and Cawthorne, M. A. (1986).Biochem. J. 237:789–795.
Steinberg, D. (1963).Biochem. Soc. Symp. 24:111–144.
Young, P., Cawthorne, M. A. and Smith, S. A. (1985).Biochem. Biophys. Res. Commun. 130:241–248.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mercer, S.W., Williamson, D.H. The influence of starvation and natural refeeding on the rate of triacylglycerol/fatty acid substrate cycling in brown adipose tissue and different white adipose sites of the ratin vivo. The role of insulin and the sympathetic nervous system. Biosci Rep 8, 147–153 (1988). https://doi.org/10.1007/BF01116459
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01116459