Abstract
Vanadium is an important trace metal widely distributed in environment. Interaction of vanadate with skeletal muscle sarcolemma and basement membrane has been focussed. Scatchard analysis indicated the presence of more than one binding site for vanadate. Vanadate inhibits sarcolemmal and intestinal brush border membrane enzymes in a non-competitive manner. Membrane-vanadium interaction may lead to several structural and functional changes. The binding of vanadium to basement membrane may have some protective role.
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Jandhyala BS, Hom GJ: Physiological and pharmacological properties of vanadium. Life Sci 33: 1325–1340, 1983
Nechay BR: Mechanisms of action of vanadium. An Rev Pharmacol Toxicol 24: 501–524, 1984
Domingo JL, Llobet JM, Tomas JM, Corbella J: Short term toxicity studies of vanadium in rats. J Appl Toxicol 5: 418–421, 1985
Miralpeic M, Gil J, Rosa JL, Carreras J, Bartrons R: Vanadate counteracts glucagon effects in isolated rat hepatocytes. Life Sci 44: 1491–1497, 1989
Hammond PB, Beliles RP: Metals In: J. Doull, C.D. Klaassen, M.O. Amdur (eds). Toxicology, the Basic Science of Poisons, MacMillan Publishing, NY, 1980 pp 460–470
Roshchin AV, Ordzhonikidze EK, Shalganova IV: Vanadium-toxicity, metabolism, carrier state. J Hyg Epidemiol Microbiol Immunol 24: 377–383, 1980
Conklin AW, Skinner CS, Felten TL, Sanders CL: Clearance and distribution of intratracheally instilled vanadium-48 compounds in the rat. Toxicol Lett 11: 199–203, 1982
Edel J, Sabbioni E: Retention of intratracheally instilled and ingested tetravalent and pentavalent vanadium in the rat. J Trace Elem Electrolytes Health Dis 2: 23–30, 1988
Parker RD, Sharma RP: Accumulation and dipletion of vanadium in selected tissues of rats treated with vanadyl sulfate and sodium orthovanadate. J Environ Pathol Toxicol. 2: 235–245, 1978
Edel J, Pietra R, Sabbioni E, Marfante E, Springer A, Ubertalli L: Disposition of vanadium in rat tissues at different age. Chemosphere 13: 87–93, 1984
Sanes JR, Marshall LM, McMahan UJ: Reinnervation of muscle fiber basal lamina after removal of myofibrils. J cell Biol 78: 176–198, 1978
Borg TK, Caulfield JB: Morphology of connective tissue in muscle. Tissue & Cell 12: 197–207, 1980
Weber A, Murray JM: Molecular control mechanism in muscle contraction. Physiol Rev 53: 612–673, 1980
Grant ME, Codfrey HJ, Orkin RW: Current concept of basement membrane structure and function. Biosci Rep 1: 819–842, 1981
Klip A, Grinstein S, Semenza G: Transmembrane disposition of the phlorizine binding protein of intestinal brush border. FEBS Lett 99: 91–96, 1979
Catalan RE, Martinez AM, Aragones MD, Godoy JE: Activation of acetylcholinesterase by vanadate. Neuropharmac 28: 1119–1122, 1985
Dufour JP, Boutry M, Goffeau A: Plasma membrane ATPase of yeast. Comparative inhibition studies of the purified and membrane bound enzymes. J Biol Chem 255: 5735–5741, 1980
Tu S-I, Sliwinski BJ: Mechanistic investigation of corn root plasma membrane ATPase. Arch Biochem Biophys 241: 348–355, 1985
Huang WH, Askari A: Simultaneous binding of ATP and vanadate to (Na++K+)-ATPase. J Biol Chem 259: 13287–13291, 1981
Dux L, Martonosi A: Ca2+-ATPase crystals in sarcoplasmic reticulum; Effect of trypsin digestion. J Biol Chem 258: 10111–10115, 1983
Kwan CY: Characteristics of plasmalemma alkaline phosphatase of rat mesentric artery. Blood Vessels 20: 109–121, 1983
Chakraborttey A, Stinson RA: Properties of membrane bound and solubilized forms of alkaline phosphatase from human liver. Biochim Biophys Acta 839: 174–180, 1985
Farley JR, Baylink DJ: Skeletal alkaline phosphatase activity as a bone formation indexin vitro. Metabol Clin Exp 35: 563–571, 1986
Nechay BR, Nanniuga LB, Nechay PSE: Vanadyl and vanadate binding to selected endogenous phosphate, carboxyl and amino ligands: Calculations of cellular vanadium species distribution. Arch Biochem Biophys 251: 128–138, 1986
Ali N, Upreti RK, Kidwai AM: Sarcolemma as model for testing toxicity of chemicals. Ind J Biochem Biophys 25: 209–214, 1988
Gupta K, Upreti RK, Kidwai AM: Toxicokinetic study of rat intestinal brush border membrane enzymes following in vitro exposure to lead and vanadium. Bull Environ Contam Toxicol 52: 919–926, 1994
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Upreti, R.K. Membrane—vanadium interaction: A toxicokinetic evaluation. Mol Cell Biochem 153, 167–171 (1995). https://doi.org/10.1007/BF01075934
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DOI: https://doi.org/10.1007/BF01075934