Abstract
Exocrine pancreatic function in 19 patients with pancreatic disease and in 14 of 16 controls was measured by secretin stimulation and by the Lundh test on two different occasions. Peak bicarbonate concentration in the secretin test and mean trypsin concentration in the Lundh test emerged as the most reliable parameters. No additional diagnostic value was obtained by measuring enzymes after secretin injection. In 6 patients with chronic and in 8 of 13 patients with acute pancreatitis, both tests gave results that agreed with each other. The remaining 5 patients showed either an abnormal secretin value or an abnormal Lundh test. This is consistent with the wide variation seen in acute pancreatitis. It is concluded that the Lundh test as well as the secretin test were of value in the assessment of chronic pancreatic disease. The secretin test may be slightly more sensitive to mild and acute pancreatic damage than is the Lundh test. However stimulation of the pancreas by a test meal is easier to perform and more economic.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Lundh G: Diagnostic investigation of the external pancreatic secretion. Bull Soc Chir 2:169–176, 1965
Lagerlöf HO: Pancreatic function and pancreatic disease. Acta Med Scand (Suppl) 128:1–289, 1942
Dreiling DA, Janowitz HD: The measurement of pancreatic secretory function, The exocrine pancreas. Ciba Foundation Symposium, Boston, Little, Brown and Co, 1962
Burton P, Evans DG, Harper AA et al: A test of pancreatic function in man based on the analysis of duodenal contents after administration of secretin and pancreozymin. Gut 1:111–124, 1960
Sun DCH: The use of pancreozymin-secretin test in the diagnosis of pancreatitis and tumors of the pancreas. Gastroenterology 45:203–208, 1963
Dreiling DA: The early diagnosis of pancreatic cancer. Scand J Gastroenterol (Suppl) 6:115–122, 1970
Lundh G: Pancreatic exocrine function in neoplastic and inflammatory disease: a simple and reliable new test. Gastroenterology 42:275–280, 1962
Kayasseh L, Stalder GA: Zur Diagnostik der Pankreasinsuffizienz. Schweiz Med Wschr 101:1624–1628, 1971
Cook HB, Lennard-Jones JE, Sherif SM et al: Measurement of tryptic activity in intestinal juice as a diagnostic test of pancreatic disease. Gut 8:408–414, 1967
Ventzke LE, Davidson WA, Grossman ML: Diagnostic value of pancreatic enzymatic response to a test meal. Gastroenterology 46:765, 1964
Moeller DD, Dunn GD, Klotz AP: Comparison of the pancreozymin-secretin test and the Lundh test meal. Am J Dig Dis 17:799–805, 1972
Hartley RC, Gambill EA, Engstrom GW, et al: Pancreatic exocrine function. Comparison of response to augmented secretin stimulus, augmented pancreozymin stimulus and test meal in health and disease. Am J Dig Dis 11:27–39, 1966
Zieve L, Mulford B, McHale A: Secretion of pancreatic enzymes. II. Comparative response following test meal or injection of secretion and pancreozymin. Am J Dig Dis 11:685–694, 1966
Fiore E, Dal Monte PR, Sasdelli M: Studio comparativo della secrezione pancreatica esocrina dopo stimulazione con pancreazimina e secretina e dopo pasto di prova. G Clin Med 48:1194–1203, 1967
Lurie B, Brom B, Bank S, et al: Comparative response of exocrine pancreatic secretion following a test meal and secretin-pancreozymin stimulation. Scand. J Gastroenterol 8:27–32, 1973
Schoen H, Rico-Irles J, Henning N: Ueber die Untersuchung der excretorischen Pancreasfunktion. II. Vergleichende Untersuchungen von Pancreasprovokationsmitteln. Klin Wschr 40:15–18, 1962
Worning H: Pancreatic secretion of amylase as compared to the amylase concentration in the intestinal contents after ingestion of a meal. Scand J Gastroenterol 6:257–260, 1971
Cherry IS, Crandall LA: The specificity of pancreatic lipase: its appearance in the blood after pancreatic injury. Am J Physiol 100:266–273, 1932
Johnson TA, Bockus HL: Diagnostic significance of determinations of serum lipase. Arch Intern Med 66:62–77, 1940
Wiggins HS: Simple method of estimating trypsin. Gut 8:415–416, 1967
Sigma Chemical Co: Sigma Chrome. The colorimetric determination of amylase. Sigma Technical Bulletin No. 550, St Louis, 1973
Somogyi M: Micromethods for the estimation of diastase. J Biol Chem 125:399–414, 1938
Remington RD, Schork MA: Statistics with applications to the biological and health sciences. Prentice Hall Inc, Englewood Cliffs NJ, 1970
Zieve L, Silvis SE, Mulford B, Blackwood WD: Secretion of pancreatic enzymes. I. Response to secretin and pancreosymin. Am J Dig Dis 11:671–684, 1966
Dreiling DA, Janowitz HD, Perrier CV: Pancreatic inflammatory disease. Harper and Row Publishers, New York, 1964
Wormsley KG: Pancreatic function tests. Clin Gastroenterol 1:27–51, 1972
Dreiling DA, Greenstein AJ, Bordalo O: The hypersecretory states of the pancreas. Am J Gastroenterol 59:505–511, 1973
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gyr, K., Agrawal, N.M., Felsenfeld, O. et al. Comparative study of secretin and Lundh tests. Digest Dis Sci 20, 506–512 (1975). https://doi.org/10.1007/BF01074934
Issue Date:
DOI: https://doi.org/10.1007/BF01074934