Abstract
From a four-way cross between unrelated inbred strains of mice, a random-breeding line was developed that segregated at two coat-color loci and carried Y chromosomes from different sources. Adult males were used for measurements of black-white discrimination learning and 7-day response retention in a water maze, body weight, brain weight, and left- and right-side hippocampus weight. Clear evidence was obtained of Y-linked influences on response acquisition, body weight, right-side hippocampus weight, and hippocampal asymmetry, whereas direct effects of autosome 9 were indicated with regard to right-side hippocampus weight only. However, epistatic interactions of the Y chromosome with autosome 9 were found for response acquisition and body weight and with autosome 4 for hippocampal asymmetry.
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van Abeelen, J.H.F., Janssens, C.J.J.G., Crusio, W.E. et al. Y-Chromosomal effects on discrimination learning and hippocampal asymmetry in mice. Behav Genet 19, 543–549 (1989). https://doi.org/10.1007/BF01066253
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DOI: https://doi.org/10.1007/BF01066253