Abstract
An attempt should be made to base analysis of problems in human behavior genetics on existing knowledge of human biochemical genetics and neurobiology. Examples for this approach are studies showing HY antigen patterns of the opposite sex in transsexuality, slight psychological deviations in heterozygotes of recessive metabolic diseases such as phenylketonuria and lipid storage diseases, and psychological studies in healthy individuals with various genetic variants of the normal human electroencephalogram (EEG). Results of such studies will help gradually to replace emotional controversy by rational assessment of facts.
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Andersen, P., and Andersson, S. A. (1968).Physiological Basis of the Alpha-Rhythm, Appleton-Century-Crofts, New York.
Batshaw, M. L., Roan, Y., Jung, A. L., Rosenberg, L. A., and Brusilov, S. W. (1980). Cerebral dysfunction in asymptomatic carriers or ornithine transcarbamylase deficiency.N. Engl. J. Med. 302:482–485.
Bleuler, M. (1972).Die schizophrenen Geistesstörungen, Thieme Verlag, Stuttgart.
Buchsbaum, M. A. (1974). Average evoked response and stimulus intensity in identical and fraternal twins.Physiol. Psychol. 2(3A):365–370.
Buchsbaum, M. S., Murphy, D. L., Coursey, R. D., Lake, C. R., and Zeigler, M. G. (1977). Platelet monoamine oxidase, plasma dopamine-beta-hydroxylase and attention in a “biochemical high-risk” sample. The nature of schizophrenia.Eur. J. Clin. Pharmacol. 11:337–344.
Christomanou, H., Martinius, J., Jaffé, S., Betke, K., and Förster, C. (1980). Biochemical, psychometric, and neuropsychological studies in heterozygotes for various lipidoses.Hum. Genet. 55:103–110.
Comings, D. E. (1979). Pc Duarte. A common polymorphism of a human brain protein, and its relationship to depressive disease and multiple sclerosis.Nature 277:28–32.
Dausset, J., and Svejgaard, A. (eds.) (1977).HLA and Disease, Munksgaard, Kopenhagen.
Dieker, H. (1967). Untersuchungen zur Genetik besonders regelmäßiger hoher Alpha-Wellen im EEG des Menschen.Humangenetik 4:189–216.
Eicher, W., Spoljar, M., Cleve, H., Murken, J.-D., Richter, K., and Stengel-Rutkowski, S. (1979). HY antigen in transsexuality.Lancet 2:1137–1138.
Engel, W., Pfäfflin, F., Wiedeking, C., and Epplen, J. T. (1980). HY antigen and transsexuality, and how to explain testis differentiation in HY antigen-negative males and ovary differentiation in HY antigen-positive females.Hum. Genet. 55:315–319.
Fischer, R. A. (1918). The correlation between relatives on the supposition of Mendelian inheritance.Trans. R. Soc. Edinburgh 52:399–433.
Harris, H. (1975).The Principles of Human Biochemical Genetics, 3rd ed., North-Holland, Amsterdam-Oxford.
Itil, T. M., (1978). Quantitative and qualitative EEG-Befunde Eis Schizophrenen.Z. EEG-EMG 9:1–13.
Matthyse, S. (1980). Genetic detection of cerebral dysfunction.N. Engl. J. Med. 302:516–517.
Perris, C., Gottfries, C. G., and v. Knorring, L. (1980). Visual averaged evoked responses in psychiatric patients. Relationship to levels of 5-hydroxyindoleacetic acid, homovanilic acid and tryptophan in cerebrospinal fluid.J. Psychiat. Res. 15:155–181.
Propping, P. (1977). Genetic control of ethanol action on the central nervous system. An EEG study in twins.Hum. Genet. 35:309.
Propping, P., Friedl, W., Nebel, B., and Feige, A. (1979). Plasma DBH, platelet MAO and proteins of red blood cell membranes in individuals with variants of the normal EEG.Neuropsychobiology 5:309–316.
Propping, P., Krüger, J., and Janah, A. (1980a). Effect of alcohol on genetically determined variants of the normal electroencephalogram.Psychiat. Res. 2:85–98.
Propping, P., Friedl, W., and Pluto, R. (1980b). Further evidence for correlation between EEG synchronization and plasma DBH activity in normal subjects.J. Neur. Transmiss. 49:167–178.
Propping, P., Krüger, J., and Mark, N. (1981). Genetic disposition to alcoholism. An EEG study in alcoholics and their relatives.Hum. Genet. (in press).
Reinke, G. (1966).Zur genetischen Grundlage der sogenannten Grenzfälle des Niederspannungs-EEGs und der diffusen β-Wellen bei jungen Männern, Dissertation, Heidelberg.
Rosenthal, D., and Kety, S. S. (eds.) (1968).The Transmission of Schizophrenia, Pergamon Press, Oxford-London.
Spoljar, M., Eicher, W., Eiermann, W., and Cleve, H. (1981). H-Y antigen expression in different tissues from transsexuals.Hum. Genet. (in press).
Thalhammer, O., Havelec, L., Knoll, E., and Wehle, E. (1977). Intellectual level (IQ) in heterozygotes for phenylketonuria (PKU).Hum. Genet. 38:285–288.
Thalhammer, O., Lubec, G., and Königshofer, H. (1979). Intracellular phenylalanine and tyrosine concentrations in 19 heterozygotes for phenylketonuria (PKU) and 26 normals.Hum. Genet. 49:333–336.
Thalhammer, O., Pollak, A., Lubec, G., and Königshofer, H. (1980). Intracellular concentrations of phenylalanine, tyrosine and alpha-aminobutyric acid in 13 homozygotes and 19 heterozygotes for phenylketonuria (PKU) compared with 26 normals.Hum. Genet. 54:213–216.
v. Knorring, L., Monakhov, K., and Perris, C. (1978). Augmenting/reducing: An adaptive switch mechanism to cope with incoming signals in healthy subjects and psychiatric patients.Neuropsychobiology 4:150–179.
Vogel, F. (1962). Ergänzende Untersuchungen zur Genetik des menschlichen Niederspannungs-EEGs.Dtsch. Z. Nervenheilk. 184:105–111.
Vogel, F. (1966a). Zur genetischen Grundlage fronto-päzentraler β-Wellen-Gruppen im EEG des Menschen.Humangenetik 2:227–237.
Vogel, F. (1966b). Zur genetischen Grundlage occipitaler langsamer β-Wellen im EEG des Menschen.Humangenetik 2:238–245.
Vogel, F. (1970). The genetic basis of the normal human electroencephalogram (EEG).Humangenetik 10:91–114.
Vogel, F., and Götze, W. (1959). Familienuntersuchungen zur Genetik des normalen Elektroencephalogramms.Dtsch. Z. Nervenheilk. 178:668–700.
Vogel, F., and Helmbold, W. (1972). Blutgruppen—Populationsgenetik und Statistik. In Becker, P. E. (ed.),Humangenetik—ein kurzes Handbuch Bd. 1, 4, Thieme Verlag, Stuttgart.
Vogel, F. and Motulsky, A. G. (1979).Human Genetics—Problems and Approaches, Springer Verlag, Berlin-Heidelberg-New York.
Vogel, F., and Schalt, E. (1979). The electroencephalogram (EEG) as a research tool in human behavior genetics: Psychological examinations in healthy males with various inherited EEG variants. III. Interpretation of the results.Hum. Genet. 47:81–11.
Vogel, F., Schalt, E., and Krüger, J. (1979a). The electroencephalogram (EEG) as a research tool in human behavior genetics: Psychological examinations in healthy males with various inherited EEG variants. I. Rationale of the study; materials; methods; heritability of test parameters.Hum. Genet. 47:1–46.
Vogel, F., Schalt, E., and Krüger, J. (1979b). The electroencephalogram (EEG) as a research tool in human behavior genetics: Psychological examinations in healthy males with various inherited EEG variants. II. Results.Hum. Genet. 47:47–80.
Weiss, V. (1979). The heritability of difference scores when environments are correlated.Biometric. J. 21:171–177.
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The author's investigations are supported by the Deutsche Forschungsgemeinschaft.
Plenary lecture given at the meeting of the Behavior Genetics Association, Chicago, June 28, 1980.
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Vogel, F. Neurobiological approaches in human behavior genetics. Behav Genet 11, 87–102 (1981). https://doi.org/10.1007/BF01065620
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DOI: https://doi.org/10.1007/BF01065620