Abstract
Capillary permeability was analyzed in both normal rat brain and intracerebral 9L gliosarcoma tumor and in rhesus monkey brain using a newly derived formula for the capillary permeability coefficient (P).The Pvalue for isotopic urea and sodium was less in monkey brain than in rat brain. The Pvalue for tumor was 1 log unit higher in tumor for all but the most rapidly transported drugs. Amphotericin B increased the normal brain Pvalue for galactitol but not for urea. Glucocorticoids did not alter brain Pvalues for sucrose or urea. Using P,drugs can be categorized in terms of blood-brain barrier (BBB) exclusion, slow BBB passage, moderate BBB passage, and rapid BBB passage. The technique described in this article is applicable to the study of regional differences in brain capillary permeability associated with disease states.
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This work was supported by NIH Grant CA-15435 and a gift from the Richard Jaenicke family.
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Levin, V.A., Landahl, H.D. & Freeman-Dove, M.A. The application of brain capillary permeability coefficient measurements to pathological conditions and the selection of agents which cross the blood-brain barrier. Journal of Pharmacokinetics and Biopharmaceutics 4, 499–519 (1976). https://doi.org/10.1007/BF01064555
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DOI: https://doi.org/10.1007/BF01064555