Summary
The effects of chelation of calcium ions and elevation of sodium ions concentration in cerebrospinal fluid on body temperature was examined in conscious dogs. Decrease of calcium ions concentration brought about by an infusion of disodium edetate (Na2EDTA) into the lateral ventricle elicited an increase in body temperature in 8 out of 10 experiments by 1.49±0.36°C. Huddling, piloerection, lowering of respiratory rate, vasoconstriction and shivering occurring in the course and after Na2EDTA infusion argue that hyperthermia resulted both from excess production of heat and activation of heat conservation mechanisms. Two intraventricular infusions of artificial CSF containing 88 mM Na+ in excess of its physiological concentration did not produce any effect on body temperature.
The role of calcium ions concentration in brain centres regulating body temperature is discussed.
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Sadowski, B., Szczepańska-Sadowska, E. The effect of calcium ions chelation and sodium ions excess in the cerebrospinal fluid on body temperature in conscious dogs. Pflugers Arch. 352, 61–68 (1974). https://doi.org/10.1007/BF01061950
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DOI: https://doi.org/10.1007/BF01061950