Abstract
A 38 year old patient developed multiple cranial nerve palsy, seizures and progressive alteration in consciousness. CSF examination revealed tumor cells and a tentative diagnosis of leptomeningeal carcinomatosis from an unknown primary tumor was made. Treatment with intrathecal methotrexate and cranial radiation therapy was started without effect. At autopsy widespread leptomeningeal gliomatosis originating from a previously unknown astrocytoma of the hippocampus was found.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Spiller WG: Gliomatosis of the pia and metastasis of glioma. J Neurol Mental Dis 34: 297–302, 1907
Cairns H, Russell DS: Intracranial and spinal metastases in gliomas of the brain. Brain 54: 377–419, 1931
Russell DS, Cairns H: Spinal metastasis in a case of cerebral glioma of the type known as astrocytoma fibrillare. J Path 33: 383–391, 1930
Eade OE, Urich H: Metastasising gliomas in young subjects. J Path 103: 245–256, 1971
McLaughlin JE: Juvenile Astrocytomas with subarachnoid spread. J Path 118: 101–107, 1976
Erlich SS, Richard LD: Spinal subarachnoid metastasis from primary intracranial glioblastoma multiforme. Cancer 42: 2854–2864, 1978
Kowano N, Miyasaka Y, Yada K, Atari H: Diffuse cerebrospinal gliomatosis. J Neurosurg 49: 303–307, 1978
Yung WKA, Horten BC, Shapiro WR: Meningeal gliomatosis: A review of 12 cases. Ann Neurol 8: 605–608, 1980
Vincent FM: Spinal leptomeningeal invasion from intracranial glioblastoma multiforme. Arch Phys Med Rehabil 64: 34–36, 1983
Packer RJ, Allen J: Brainstem glioma: Clinical manifestations of meningeal gliomatosis. Ann Neurol 14:177–182, 1983
Awad I, Bay JW, Rogers L: Leptomeningeal metastasis from supratentorial malignant gliomas. Neurosurgery 19: 247–251, 1986
Choucair AK, Levin VA: Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas. J Neurosurg 65: 654–658, 1986
Vries EP, Visser M, Troost D: Supratentorial meningeal spread from brainstem glioma. J Neurol Neurosurg Psychiatry 1011–1013, 1989
Delattre JY, Walker RW, Rosenblum MK: Leptomeningeal gliomatosis with spinal cord or cauda equina compression: a complication of supratentorial gliomas in adults. Acta Neurol Scand 79: 133–139, 1989
Korein J, Feigin I, Shapiro M: Oligodendrogliomatosis with intracranial hypertension. Neurology 7: 589–594, 1957
Sumi SM, Leffman H: Primary intracranial leptomeningeal glioma with persistent hypoglycorrhachia. J Neurol Neurosurg Psychiatry 31: 190–194, 1968
Bhrany D, Murphy M, Horenstein S, Silbert S: Diffuse periventricular and meningeal glioma. Acta Neuropath (Berl) 30: 243–249, 1974
Simonatti A, Mazza C, Rizzuto N: An unusual case of meningeal gliomatosis. Acta Neuropathol (Berl) Suppl VII 97–100, 1981
Ho KL, Hoschner JA, Wolfe DE: Primary leptomeningeal gliomatosis. Symptoms suggestive of meningitis. Arch Neurol 38: 662–666, 1981
Kitahara M, Katakura R, Wada T, Namiki T, Suzuki J: Diffuse form of primary leptomeningeal gliomatosis. J Neurosurg 63: 283–287, 1985
Polmeter FE, Hernohan JW: Meningeal gliomatosis. Arch Neurol Psych 57: 593–616, 1974
Cooper I, Kernohan J: Heterotopic glial nests in subarach-noid space: Histopathologic characteristics, mode of origin and relation to meningeal gliomas. J Neuropath Exp Neurol 10: 16–29, 1951
Russel DS, Rubinstein LJ. Pathology of tumors of the nervous system. Arnold, London, 4th ed, 1977, p 26–27, 341–347
Wechsler LR, Gross RA, Miller DC: Meningeal gliomatosis with negative CSF cytology: The value of GFAP staining. Neurology 34: 1611–1615, 1984
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Davila, G., Duyckaerts, C., Lazareth, J.P. et al. Diffuse primary leptomeningeal gliomatosis. J Neuro-Oncol 15, 45–49 (1993). https://doi.org/10.1007/BF01050262
Issue Date:
DOI: https://doi.org/10.1007/BF01050262