Summary
The main product of fermentation byKlebsiella oxytoca is 2,3-butanediol. This organism also produces acetic acid, ethanol, and acetoin. In this report, product inhibition due to 2,3-butanediol and acetic acid is considered. Although the acetate ion has little effect on growth, acetic acid is a strong inhibitor. Acetic acid inhibits growth more strongly than it inhibits respiration. The neutral product 2,3-butanediol is not a strong inhibitor; its effect on growth is no more than is expected by the decrease in water activity it causes. The effect of 2,3-butanediol on respiration can also be explained by a decreased water activity. It appears that it is possible to accumulate as much as 130 g/L butanediol while as little as 0.45 g/L acetic acid completely inhibits growth.
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Fond, O., Jansen, N.B. & Tsao, G.T. A model of acetic acid and 2,3-butanediol inhibition of the growth and metabolism ofKlebsiella oxytoca . Biotechnol Lett 7, 727–732 (1985). https://doi.org/10.1007/BF01032284
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DOI: https://doi.org/10.1007/BF01032284