Summary
Increased production of catharanthine (about 200 μg/mL) was obtained at low light intensity under chemostat cultivation as compared with batch and fed-batch processes. Photo-inhibition was observed at high light intensity. Cells after being frozen with 5% DMSO produced more catharanthine (up to 350 μg/L) in batch culture than those from conventional culture techniques.
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Park, H.H., Choi, S.K., Kang, J.K. et al. Enhancement of producing catharanthine by suspension growth ofCatharanthus roseus . Biotechnol Lett 12, 603–608 (1990). https://doi.org/10.1007/BF01030760
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DOI: https://doi.org/10.1007/BF01030760