Zusammenfassung
Innerhalb weniger Stunden nach Bildung eines Thrombus in einer Hirnarterie wurden bei 220 Patienten die DeformabilitÄt and AggregabilitÄt der Erythrozyten untersucht. Die Filtration von gewaschenen Erythrozyten zeigte bei 27,5% der Patienten VerÄnderungen der DeformabilitÄt. Die Filtration ungewaschener Erythrozyten ergab bei 78,6% der Patienten eine Zunahme der AggregabilitÄt der Erythrozyten. Die Berechnung der Korrelationskoeffizienten zwischen Filtrations-index und Fibrinogenkonzentration, die bei 88,2% der Patienten erhöht war, weist darauf hin, da\ Störungen der AggregabilitÄt nur bei Patienten mit den Blutgruppen A und B abhÄngig von Fibrinogen sind, wÄhrend es sich bei den Blutgruppen 0 und AB um andere Plasmafaktoren handeln mu\.
Summary
Within a few hours after a cerebral thrombosis in 220 patients, the flow-properties of the red blood cells (RBC) were analyzed by a filtration test that expresses quantitatively the deformability and aggregability of the RBC by the filtration indexes pT. Abnormal deformability of the RBC washed clean of plasma was found in 27.5% of the patients. Aggregability disorders, caused by the plasma trapped between the unwashed RBC, were found in 78.6 % of the patients: computation of correlation coefficients between pT indexes and fibrinogen, which was found abnormally high in 88.2% of cases, demonstrated significantly that in the patients with A and B blood groups these aggregability disorders were due to fibrinogen and that they were caused by other components of plasma in patients with O and AB blood groups. All these disorders can account for blood hyperviscosity.
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Ionescu, D.A., Ghitescu, M., Marcu, I. et al. Erythrocyte rheology in acute cerebral thrombosis effects of ABO blood groups. Blut 39, 351–357 (1979). https://doi.org/10.1007/BF01014198
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DOI: https://doi.org/10.1007/BF01014198