Summary
Chemotherapeutic agents available for use against toxoplasmosis are usually not suitable for prophylactic purposes because of their toxicity. The observed increasing number of activated latent infections withToxoplasma, especially in immune suppressed patients, requires that safe techniques are available for use during the patients' regression period.
Pretreatment of mice withToxoplasma killed by irradiation appeared to induce resistance to challenge with virulent organisms. Survival times of six months have been observed to date. Increasing effectiveness was seen after more than one administration.
Further investigation into the duration of effective resistance is needed; the question of at which intervals subsequent inoculations should be performed in order to acquire a booster effect, if any, has still to be solved before application to man can be recommended.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Kobayashi, A., Jacobs, L.: The effect of irradiation onToxoplasma gondii. J. Parasitol.49, 814–818 (1963)
Lund, E., Lycke, E., Sourander, P.: Studies ofToxoplasma gondii in cellcultures by means of irradiation experiments. Br. J. Exp. Pathol.42, 404–407 (1961)
Ruskin, J., Remington, J. S.: Toxoplasmosis in the compromised host. Ann. Intern. Med.84, 193–199 (1976)
Seah, S.K.K., Hucal, G.: Immunization against experimental toxoplasmosis. In: Proceedings 1, Third International Congress Parasitology, pp. 289–290 (1974). Vienna: Facta Publication, Verlag H. Egermann (1974)
Seah, S.K.K., Hucal, G.: The use of irradiated vaccine in immunization against experimental murine toxoplasmosis. Can. J. Microbiol.21, 1379–1385 (1975)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bakal, P.M., Veld, N.i. Response of white mice to inoculation of irradiated organisms of theToxoplasma strain RH. Z. Parasitenkd. 59, 211–217 (1979). https://doi.org/10.1007/BF00927515
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00927515