Abstract
Retinal exudates are a common manifestation of vascular damage in a variety of retinal diseases. We have used computerized image analysis to detect and measure the area of exudates from digitized colour fundus slides of patients with diabetic retionpathy and have assessed the repeatability, reproducibility, and accuracy of the technique. The analysis was entirely independent of the operator apart from choice of the region to be analysed. The coefficient of variation for repeatability was between 3% for large areas of exudate and 17% for small areas of exudate. The reproducibility was also within this range. Sensitivity was between 61 and 100% o (mean 87%). False-positives were observed in 5 of 30 regions analysed, and these could have been eliminated by using more stringent criteria for selection of images for analysis. Time taken for the analysis was approximately 3 min.
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References
The Diabetic Retinopathy Study Research Group (1981) A modification of the Airlie House Classification of diabetic retinopathy: Diabetic Retinopathy Study: report no. 7. Invest Ophthalmol Vis Sci 21:210–226
Jagoe JR, Blauth CI, Smith PL, Arnold JV, Taylor RM, Wooton R (1990) Quantification of retinal damage during cardiopulmonary bypass: comparison of computer and human assessment. Procs IEEE 137:170–175
Katz N, Goldbaum M, Nelson M, Chaudhuri S (1988) An image processing system for automatic retinal diagnosis. Procs SPIE 902:131–137
Phillips RP, Ross PGB, Tyszka M, Sharp PF, Forrester JV (1991) Detection and quantification of hypofluorescent leakage by computer analysis of fundus fluorescein angiograms. Graefe's Arch Clin Exp Ophthalmol 229:329–335
Rosenfeld A, Kak AC (1982) Digital picture processing. Academic Press, Orlando, pp 61–73; 254–263
Spencer T, Phillips RP, Sharp PF, Forrester JV (1992) Automated detection and quantification of microaneurysms in fluorescein angiograms. Graefe's Arch Cli Exp Ophthalmol 230:36–41
Ward NP, Tomlinson S, Taylor CJ (1989) Image analysis of fundus photographs. The detection and measurement of exudates associated with diabetic retinopathy. Ophthalmology 96:80–86
Webb RH, Hughes GW, Delori FC (1987) Confocal scanning laser ophthalmoscope Appl Optics 26:1492–1499
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This work was supported by grants from: The Scottisch Home and Health Department, The Scottish Hospital Endowments Research Trust, The TFC Frost Trust, and Grampian Health Board.
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Phillips, R., Forrester, J. & Sharp, P. Automated detection and quantification of retinal exudates. Graefe's Arch Clin Exp Ophthalmol 231, 90–94 (1993). https://doi.org/10.1007/BF00920219
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DOI: https://doi.org/10.1007/BF00920219