Abstract
Thirty-one children, selected for marked inattention and overactivity, were studied in a double-blind, placebo-controlled crossover study of essential fatty acid (EFA) supplementation. Subjects received the active treatment and placebo conditions for 4 weeks each and were assessed on a variety of cognitive, motor, and standardized rating scale measures. EFA supplementation (evening primrose oil; Efamol®) resulted in significantly lower levels of palmitoleic acid (a nonessential fatty acid) and higher concentrations of dihomogammalinolenic acid, an EFA previously found to be deficient in some hyperactive children. Supplementation was also associated with significant changes on two performance tasks and with significant improvement to parent ratings on the subscales designated as Attention Problem and Motor Excess of the Revised Behavior Problem Checklist. However, a variety of eight other psychomotor performance tests and two standardized teacher rating scales failed to indicate treatment effects. When the experimentwise probability level was set at.05, only 2 of 42 variables showed treatment effects. Baseline EFA concentrations appeared to be unrelated to treatment response. It was concluded that EFA supplementation, as employed here, produces minimal or no improvements in hyperactive children selected without regard to baseline EFA concentrations.
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Alvey, N. G., Banfield, C. F., Baxter, R. I., Gower, J. C., Kranowski, W. J., Lane, P. W., Leech, P. K., Neider, J. A., Payne, R. W., Phelps, K. M., Rogers, C. E., Ross, G. J. S., Simpson, H. R., Todd, A. P., Wedderburn, R. W., & Wilkinson, G. N. (1977).Genstat-A general statistical program. Harpenden Hartfordshire, U.K.: Statistics Department, Rothamsted Experimental Station.
Aman, M. G. (1978). Drugs, learning, and the psychotherapies. In J. S. Werry (Ed.),Pediatric psychopharmacology: The use of behavior modifying drugs in children (pp. 79–108). New York: Brunner/Mazel.
Aman, M. G. (1984). Hyperactivity: Nature of the syndrome and its natural history.Journal of Autism and Developmental Disorders, 14, 39–56.
Aman, M. G., & Turbott, S. H. (1986). Incidental learning, distraction, and sustained attention in hyperactive and control subjects.Journal of Abnormal Child Psychology, 14, 441–455.
Aman, M. G., & Wakeman, P. (1981). A simple system for control of the continuous performance test in psychopharmacological research.Progress in Neuro-Psychopharmacology, 4, 621–626.
Aman, M. G. & Werry, J. S. (1984). The Revised Behavior Problem Checklist in clinic attenders and non-attenders: Age and sex effects.Journal of Clinical Child Psychology, 13, 237–242.
Aman, M. G., Werry, J. S., Fitzpatrick, J., Lowe, M., & Waters, J. (1983). Factor structure and norms for the Revised Behavior Problem Checklist in New Zealand children.Australian and New Zealand Journal of Psychiatry, 17, 354–360.
American Psychiatric Association. (1980).Diagnostic and statistical manual of mental disorders (3rd ed.). Washington, D.C.: Author.
Colquhoun, I., & Bunday, S. (1981). A lack of essential fatty acids as a possible cause of hyperactivity in children.Medical Hypotheses, 7, 673–679.
Conners, C. K. (1969). A teacher rating scale for use in drug studies with children.American Journal of Psychiatry, 126, 152–156.
Feingold, B. F. (1974).Why your child is hyperactive. New York: Random House.
Guy, W. (1976).ECDEU assessment manual for psychopharmacology (rev. ed.). Rockville, Maryland: U.S. Department of Health, Education and Welfare.
Hale, G. A., & Morgan, J. S. (1973). Developmental trends in children's component selection.Journal of Experimental Child Psychology, 15, 302–314.
Hale, G. A., & Taweel, J. S. (1974). Children's component selection with varying degrees of training.Journal of Experimental Child Psychology, 17, 229–241.
Horrobin, D. F. (1981). Prostaglandins essential fatty acids and psychiatric disorders: A background review. In D. F. Horrobin (Ed.),Clinical uses of essential fatty acids. (Proceedings of the first Efamol symposium held in London, England) (pp. 167–174). London: Eden Press.
Kagan, J. (1965). Reflection-impulsivity and reading ability in primary grade children.Child Development, 36, 609–628.
Klove, H. (1963). Clinical neuropsychology. In F. M. Forster (Ed.),The medical clinics of North America (pp. 1647–1658). New York: Saunders.
Manku, M. S., Horrobin, D. F., Huang, Y. S., & Morse, N. (1983). Fatty acids in plasma and red cell membranes in normal humans.Lipids, 18, 906–908.
Milich, R., Loney, J., & Landau, S. (1982). Independent dimensions of hyperactivity and aggression: A validation with playroom observational data.Journal of Abnormal Psychology, 91, 183–198.
Mitchell, E. A., Aman, M. G., Turbott, S. H., & Manku, M. (1986).Clinical characteristics and serum essential fatty acid levels in hyperactive children. Manuscript submitted for publication.
Mitchell, E. A., Lewis, S., & Cutler, D. R. (1983). Essential fatty acids and maladjusted behavior in children.Prostaglandins, Leukotrienes and Medicine, 12, 281–287.
O'Leary, K. D. (1981). Assessment of hyperactivity: Observational and rating methodologies. In S. A. Miller (Ed.),Nutrition and behavior (pp. 291–298). Philadelphia: Fauklin Institute Press.
Quay, H. C. (1983). A dimensional approach to children's behavior disorders: The Revised Behavior Problem Checklist.School Psychology Review, 12, 244–249.
Reeves, J. C., Werry, J. S., Elkind, G. S., & Zametkin, A. (in press). Attention defecit, conduct, oppositional and anxiety disorders in children: II Clinical characteristics.Journal of the American Academy of Child Psychiatry.
Rosvold, A., Mirsky, A., Sarason, I., Bransome, E., & Beck, L. (1956). A continuous performance test of brain damage.Journal of Consulting Psychology, 20, 343–350.
Sprague, R. L., & Sleator, E. K. (1977). Methylphenidate in hyperkinetic children: Differences in dose effects on learning and social behavior.Science, 198, 1274–1276.
Sprague, R. L., & Toppe, L. K. (1966). Relationship between activity level and delay of reinforcement.Journal of Experimental Psychology, 3, 390–397.
Ullmann, R. K., Sleator, E. K., & Sprague, R. L. (1984). A new rating scale for diagnosis and monitoring of ADD children.Psychopharmacology Bulletin, 20, 160–164.
Wechsler, D. (1974).Manual for the Wechsler Intelligence Scale for Children-Revised. New York: Psychological Corporation.
Werry, J. S., & Aman, M. G. (1975). Methylphenidate and haloperidol in children. Effects on attention, memory, and activity.Archives of General Psychiatry, 32, 790–795.
Werry, J. S., Aman, M. G., & Diamond, E. (1980). Imipramine and methylphenidate in hyperactive children.Journal of Child Psychology and Psychiatry, 21, 27–35.
Werry, J. S., & Hawthorne, D. (1976). Conners teacher questionnaire -Norms and validity.Australian and New Zealand Journal of Psychiatry, 10, 257–262.
Wright, S., & Burton, J. L. (1982). Oral evening-primrose-seed oil improves atopic eczema.The Lancet, 1, 1120–1122.
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This study was supported by grants from Efamol Research Inc., and the Medical Research Council of New Zeland. We thank Messers. Patrick Flynn and Mark Norwood for carrying out the statistical analyses.
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Aman, M.G., Mitchell, E.A. & Turbo, S.H. The effects of essential fatty acid supplementation by efamol in hyperactive children. J Abnorm Child Psychol 15, 75–90 (1987). https://doi.org/10.1007/BF00916467
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DOI: https://doi.org/10.1007/BF00916467